KIN

Gene Symbol	KIN
Entrez Gene	22944
Alt Symbol	BTCD, KIN17, Rts2
Species	Human
Gene Type	protein-coding
Description	Kin17 DNA and RNA binding protein
Other Description	DNA/RNA-binding protein KIN17|KIN, antigenic determinant of recA protein homolog|binding to curved DNA
Swissprots	O60870 B4DX32
Accessions	EAW86374 O60870 AA768850 AJ005273 CAA06462 AK296637 BAH12407 AK301789 BAG63244 AK309059 BC017309 AAH17309 BC037913 BX504040 XM_006717434 XP_006717497 XM_006717435 XP_006717498 XM_011519427 XP_011517729 XR_930485 NM_012311 NP_036443 NR_045609 NR_045610
Function	Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485, ECO:0000269|PubMed:17045609}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Cytoplasm {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}.
Tissue Specificity	Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level). {ECO:0000269|PubMed:10964102, ECO:0000269|PubMed:9266022}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KIN - MBS1272337 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC017309

Human KIN ORF Clone(NM_012311.3) - CDCL168063 from Creative Biomart Species Human Accession NM_012311.3

Human KIN/KIN17 Gene ORF cDNA clone in cloning vector - HG14892-G from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14892-NM from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14892-ANG from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14892-NY from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14892-CM from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, N-His tag - HG14892-NH from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, C-His tag - HG14892-CH from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14892-CY from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14892-ACR from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14892-ANR from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14892-NF from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid - HG14892-UT from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14892-ACG from Sino Biological Species Human

Human KIN/KIN17 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14892-CF from Sino Biological Species Human

Human KIN ORF Clone (BC017309) - CDCS413286 from Creative biogene Species Human Accession O60870

Human KIN ORF clone (BC017309) - CDCB158681 from Creative biogene Species Human

Human KIN Gene cDNA Clone - orb143974 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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