| Gene Symbol |
MEOX2
|
| Entrez Gene |
4223
|
| Alt Symbol |
GAX, MOX2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mesenchyme homeobox 2
|
| Other Description |
growth arrest-specific homeobox|homeobox protein MOX-2
|
| Swissprots |
P50222 O75263 B2R8I7 Q9UPL6
|
| Accessions |
AAC06184 AAC33152 EAL24289 EAW93666 P50222 AK309472 AK313386 BAG36184 BC017021 AAH17021 BQ025060 CR536553 CAG38790 DA586635 L36328 AAA58497 X82629 CAA57949 NM_005924 NP_005915
|
| Function |
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. {ECO:0000250|UniProtKB:P32443, ECO:0000269|PubMed:22206000}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19266028, ECO:0000269|PubMed:22206000}. Nucleus speckle {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:19266028}.
|
| Tissue Specificity |
Embryo and placenta.
|