Gene Symbol | MEOX2 |
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Entrez Gene | 4223 |
Alt Symbol | GAX, MOX2 |
Species | Human |
Gene Type | protein-coding |
Description | mesenchyme homeobox 2 |
Other Description | growth arrest-specific homeobox|homeobox protein MOX-2 |
Swissprots | P50222 O75263 B2R8I7 Q9UPL6 |
Accessions | AAC06184 AAC33152 EAL24289 EAW93666 P50222 AK309472 AK313386 BAG36184 BC017021 AAH17021 BQ025060 CR536553 CAG38790 DA586635 L36328 AAA58497 X82629 CAA57949 NM_005924 NP_005915 |
Function | Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. {ECO:0000250|UniProtKB:P32443, ECO:0000269|PubMed:22206000}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19266028, ECO:0000269|PubMed:22206000}. Nucleus speckle {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:19266028}. |
Tissue Specificity | Embryo and placenta. |
MOX-2 CRISPR/Cas9 KO Plasmid (h) - sc-403723 from Santa Cruz Biotechnology
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MOX-2 HDR Plasmid (h) - sc-403723-HDR from Santa Cruz Biotechnology
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MOX-2 Double Nickase Plasmid (h) - sc-403723-NIC from Santa Cruz Biotechnology
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MOX-2 Double Nickase Plasmid (h2) - sc-403723-NIC-2 from Santa Cruz Biotechnology
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MOX-2 CRISPR Activation Plasmid (h) - sc-403723-ACT from Santa Cruz Biotechnology
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MOX-2 CRISPR Activation Plasmid (h2) - sc-403723-ACT-2 from Santa Cruz Biotechnology
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MOX-2 Lentiviral Activation Particles (h) - sc-403723-LAC from Santa Cruz Biotechnology
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MOX-2 Lentiviral Activation Particles (h2) - sc-403723-LAC-2 from Santa Cruz Biotechnology
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MOX-2 siRNA (h) - sc-106233 from Santa Cruz Biotechnology
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MOX-2 shRNA Plasmid (h) - sc-106233-SH from Santa Cruz Biotechnology
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MOX-2 shRNA (h) Lentiviral Particles - sc-106233-V from Santa Cruz Biotechnology
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MEOX 2 RNAi - H00004223-R01 from Novus Biologicals
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MISSION® esiRNA - EHU022491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13205 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13205 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08486 from Sigma-Aldrich
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MEOX2 siRNA (Human) - CRH2872 from Cohesion Biosciences
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shRNA set against Human MEOX2 (NM_005924.4) - SHH340415 from Creative biogene
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shRNA set against Human MEOX2(NM_005924.4) - SHH184709 from Creative biogene
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Human MEOX2 siRNA - orb263374 from Biorbyt
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MEOX2 shRNA Plasmid (Human) - CHH2872 from Cohesion Biosciences
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MEOX2 miRNA 3'UTR clone - MiUTR1H-06207 from Creative biogene
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