SETD1B

Gene Symbol	SETD1B
Entrez Gene	23067
Alt Symbol	KMT2G, Set1B
Species	Human
Gene Type	protein-coding
Description	SET domain containing 1B
Other Description	SET domain-containing protein 1B\|hSET1B\|histone-lysine N-methyltransferase SETD1B\|lysine N-methyltransferase 2G
Swissprots	F6MFW1 Q9UPS6
Accessions	Q9UPS6 AB028999 BAA83028 AK000810 BC047909 BC080192 JF813787 AEG67286 XM_005253858 XP_005253915 XM_006719296 XP_006719359 XM_011538053 XP_011536355 NM_015048 NP_055863
Function	Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
Subcellular Location	Nucleus speckle {ECO:0000269\|PubMed:17355966}. Chromosome {ECO:0000269\|PubMed:17355966}. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.
Top Pathways	Lysine degradation

Set1B (F-19) - sc-248564 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Set1B (F-19): sc-248564. Western blot analysis of Set1B expression in Hep G2 whole cell lysate.

Set1B (N-20) - sc-248563 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Set1B (N-20): sc-248563. Western blot analysis of Set1B expression in NIH/3T3 whole cell lysate (A) and mouse heart tissue extract (B).

Anti-KMT2G / hSET1B antibody - ab113984 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling KMT2G / hSET1B with ab113984 at 1/1000 (1µg/ml). Detection: DAB.

Anti-KMT2G / hSET1B antibody - ab113964 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling KMT2G / hSET1B with ab113964 at 1/1000 (1µg/ml). Detection: DAB.

Anti-KMT2G / hSET1B antibody - ab112049 from Abcam

Prices	$428.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Staining of Human KMT2G / hSET1B in a Formalin/PFA-fixed paraffin-embedded section of Human Breast Carcinoma using ab112049 at a dilution of 1/250.

Anti-KMT2G / hSET1B antibody - C-terminal - ab170645 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KMT2G / hSET1B antibody - C-terminal (ab170645) at 1/100 dilution + Mouse heart tissue lysates at 35 µg

Anti-SETD1B / SET1B Antibody (aa1400-1450) - LS-C289033 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human hSET1B by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-hSET1B used at a dilution of 1:1000 (1 Detection: DAB.

Anti-SETD1B / SET1B Antibody (aa350-400) - LS-C289032 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human hSET1B by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-hSET1B used at a dilution of 1:1000 (1 Detection: DAB.

Anti-SETD1B / SET1B Antibody (aa350-400) - LS-C286848 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SETD1B / SET1B Antibody (aa685-720, APC) - LS-C217455 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SETD1B / SET1B Antibody (aa685-720, AP) - LS-C217456 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SETD1B / SET1B Antibody (aa685-720, Biotin) - LS-C217457 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SETD1B / SET1B Antibody (aa685-720, Azide-free, HRP) - LS-C217459 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SETD1B / SET1B Antibody (aa685-720, FITC) - LS-C217458 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SETD1B / SET1B Antibody (aa685-720, PE) - LS-C217460 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SETD1B / SET1B Antibody (aa685-720) - LS-C325022 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SETD1B / SET1B Antibody - LS-C332048 from LifeSpan Bioscience

Prices	$305.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SETD1B / SET1B Antibody - LS-C347716 from LifeSpan Bioscience

Prices	$345.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SETD1B / SET1B Antibody (aa1806-1839) - LS-C169001 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

SET1B Antibody western blot of mouse heart tissue lysates (35 ug/lane). The SET1B antibody detected the SET1B protein (arrow).

SET1B Antibody - NBP1-28685 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: SET1B Antibody [NBP1-28685] - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-hSET1B used at a dilution of 1:1,000 (1ug/ml). Detection: DAB

SET1B Antibody - NBP1-28684 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: SET1B Antibody [NBP1-28684] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-hSET1B used at a dilution of 1:1,000 (1ug/ml). Detection: DAB

SET1B Antibody - NBP1-87896 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ANTI-SET1B (C-TERM) antibody produced in rabbit - SAB1304689 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-SET1B (C-term): <B>Cat. No. SAB1304689 </B>: SET1B Antibody (C-term) western blot analysis in mouse heart tissue lysates (35 μg/lane).

Anti-SETD1B antibody produced in rabbit - HPA021667 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-SETD1B: <B>Cat. No. HPA021667</B>: Immunohistochemical staining of human urinary bladder shows strong nuclear positivity.

SET1B-Antibody-C-term - AP12413b from Abgent, a WuXi AppTec company

Prices	$95.00, $265.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal

SET1B Antibody (C-term) (Cat. #AP12413b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the SET1B antibody detected the SET1B protein (arrow).

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