SETD1B

Gene Symbol	SETD1B
Entrez Gene	23067
Alt Symbol	KMT2G, Set1B
Species	Human
Gene Type	protein-coding
Description	SET domain containing 1B
Other Description	SET domain-containing protein 1B|hSET1B|histone-lysine N-methyltransferase SETD1B|lysine N-methyltransferase 2G
Swissprots	F6MFW1 Q9UPS6
Accessions	Q9UPS6 AB028999 BAA83028 AK000810 BC047909 BC080192 JF813787 AEG67286 XM_005253858 XP_005253915 XM_006719296 XP_006719359 XM_011538053 XP_011536355 NM_015048 NP_055863
Function	Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:17355966}. Chromosome {ECO:0000269|PubMed:17355966}. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SETD1B / SET1B Antibody Blocking Peptide - LS-E1652 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SET1B-Antibody-C-term-Blocking-peptide - BP12413b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Histone-lysine N-methyltransferase SETD1B(SETD1B) ,partial - CSB-YP892167HU CSB-EP892167HU CSB-BP892167HU CSB-MP892167HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human SET1B Complex Protein, His/GST-tagged - SETD1B-185H from Creative Biomart Category Protein Source E.coli Species Human

SET1B Recombinant Protein Antigen - NBP1-87896PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SETD1B Peptide, Human - M34GP14078H from Creative Peptides Category Peptide Source Synthetic. Species Human

SET1B Recombinant Protein Antigen - NBP2-55848PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Histone-lysine N-methyltransferase SETD1B (SETD1B), partial, Recombinant Protein - MBS1485202 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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