| Gene Symbol |
SETD1B
|
| Entrez Gene |
23067
|
| Alt Symbol |
KMT2G, Set1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SET domain containing 1B
|
| Other Description |
SET domain-containing protein 1B|hSET1B|histone-lysine N-methyltransferase SETD1B|lysine N-methyltransferase 2G
|
| Swissprots |
F6MFW1 Q9UPS6
|
| Accessions |
Q9UPS6 AB028999 BAA83028 AK000810 BC047909 BC080192 JF813787 AEG67286 XM_005253858 XP_005253915 XM_006719296 XP_006719359 XM_011538053 XP_011536355 NM_015048 NP_055863
|
| Function |
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:17355966}. Chromosome {ECO:0000269|PubMed:17355966}. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.
|
| Top Pathways |
Lysine degradation
|