SETD1B

Gene Symbol SETD1B
Entrez Gene 23067
Alt Symbol KMT2G, Set1B
Species Human
Gene Type protein-coding
Description SET domain containing 1B
Other Description SET domain-containing protein 1B|hSET1B|histone-lysine N-methyltransferase SETD1B|lysine N-methyltransferase 2G
Swissprots F6MFW1 Q9UPS6
Accessions Q9UPS6 AB028999 BAA83028 AK000810 BC047909 BC080192 JF813787 AEG67286 XM_005253858 XP_005253915 XM_006719296 XP_006719359 XM_011538053 XP_011536355 NM_015048 NP_055863
Function Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
Subcellular Location Nucleus speckle {ECO:0000269|PubMed:17355966}. Chromosome {ECO:0000269|PubMed:17355966}. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.
Top Pathways Lysine degradation

Set1B CRISPR/Cas9 KO Plasmid (h) - sc-406129 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1B HDR Plasmid (h) - sc-406129-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1B Double Nickase Plasmid (h) - sc-406129-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1B Double Nickase Plasmid (h2) - sc-406129-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1B CRISPR Activation Plasmid (h) - sc-406129-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1B CRISPR Activation Plasmid (h2) - sc-406129-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1B Lentiviral Activation Particles (h) - sc-406129-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1B Lentiviral Activation Particles (h2) - sc-406129-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1B siRNA (h) - sc-95750 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Set1B shRNA Plasmid (h) - sc-95750-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Set1B shRNA (h) Lentiviral Particles - sc-95750-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU137261 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN19166 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19166 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SETD1B siRNA (Human) - CRH7974 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SETD1B - MBS8237803 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SETD1B (NM_015048.1) - SHH405580 from Creative biogene

Category siRNA
Species Reactivities Human

Set1B CRISPR/Cas9 KO Plasmid (h2) - sc-406129-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1B HDR Plasmid (h2) - sc-406129-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Human SETD1B siRNA - orb268476 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SETD1B shRNA Plasmid (Human) - CHH7974 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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