Gene Symbol | UBP1 |
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Entrez Gene | 7342 |
Alt Symbol | LBP-1B, LBP-1a, LBP1A, LBP1B |
Species | Human |
Gene Type | protein-coding |
Description | upstream binding protein 1 (LBP-1a) |
Other Description | transcription factor LBP-1|upstream-binding protein 1 |
Swissprots | Q9UD76 Q9H8V0 Q9NZI7 Q68CT0 Q9UD78 Q86Y57 |
Accessions | EAW64454 EAW64455 EAW64456 EAW64457 Q9NZI7 AF198487 AAF32274 AK023274 BAB14501 AK023278 BAG51180 AK023322 AK027177 AK293100 BAF85789 AK309430 AL133032 AL831847 BC047235 AAH47235 CR749798 CAH18658 DB131031 EU446907 ABZ92436 XM_011534077 XP_011532379 XR_940498 NM_001128160 NP_001121632 NM_001128161 NP_001121633 NM_014517 NP_055332 |
Function | Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. {ECO:0000250, ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:2006421, ECO:0000269|PubMed:8114710}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:8114710}. |
Tissue Specificity | Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines. {ECO:0000269|PubMed:10644752}. |
LBP1 (G-15) - sc-70069 from Santa Cruz Biotechnology
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LBP1 (H-40) - sc-367482 from Santa Cruz Biotechnology
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LBP1 (N-14) - sc-70070 from Santa Cruz Biotechnology
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LBP1 (P-20) - sc-70071 from Santa Cruz Biotechnology
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LBP1 (S-20) - sc-70072 from Santa Cruz Biotechnology
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LBP1 (T-18) - sc-70073 from Santa Cruz Biotechnology
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LBP1 (P-22) - sc-133727 from Santa Cruz Biotechnology
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LBP1 (327C1a) - sc-81310 from Santa Cruz Biotechnology
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Anti-Upstream Binding Protein 1 antibody - ab30965 from Abcam
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Anti-Upstream Binding Protein 1 antibody - ab131139 from Abcam
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Anti-Upstream Binding Protein 1 antibody - ab116673 from Abcam
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Anti-Upstream Binding Protein 1 antibody - ab58268 from Abcam
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Anti-Upstream Binding Protein 1 antibody - ab99553 from Abcam
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Anti-Upstream Binding Protein 1 antibody [327C1a] - ab54372 from Abcam
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Anti-UBP1 Antibody - LS-C76702 from LifeSpan Bioscience
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Anti-UBP1 Antibody (aa266-295, APC) - LS-C224584 from LifeSpan Bioscience
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Anti-UBP1 Antibody (aa266-295, AP) - LS-C224583 from LifeSpan Bioscience
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Anti-UBP1 Antibody (aa266-295, Biotin) - LS-C224585 from LifeSpan Bioscience
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Anti-UBP1 Antibody (aa355-404) - LS-C29942 from LifeSpan Bioscience
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Anti-UBP1 Antibody (aa266-295, Azide-free, HRP) - LS-C224587 from LifeSpan Bioscience
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Anti-UBP1 Antibody (clone 327C1a) - LS-C184539 from LifeSpan Bioscience
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Anti-UBP1 Antibody (aa266-295, FITC) - LS-C224586 from LifeSpan Bioscience
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Anti-UBP1 Antibody (aa266-295, PE) - LS-C224588 from LifeSpan Bioscience
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Anti-UBP1 Antibody (clone 1C5) - LS-C198400 from LifeSpan Bioscience
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Anti-UBP1 Antibody (aa1-541, Azide-free) - LS-C329019 from LifeSpan Bioscience
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