| Gene Symbol |
UBP1
|
| Entrez Gene |
7342
|
| Alt Symbol |
LBP-1B, LBP-1a, LBP1A, LBP1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
upstream binding protein 1 (LBP-1a)
|
| Other Description |
transcription factor LBP-1|upstream-binding protein 1
|
| Swissprots |
Q9UD76 Q9H8V0 Q9NZI7 Q68CT0 Q9UD78 Q86Y57
|
| Accessions |
EAW64454 EAW64455 EAW64456 EAW64457 Q9NZI7 AF198487 AAF32274 AK023274 BAB14501 AK023278 BAG51180 AK023322 AK027177 AK293100 BAF85789 AK309430 AL133032 AL831847 BC047235 AAH47235 CR749798 CAH18658 DB131031 EU446907 ABZ92436 XM_011534077 XP_011532379 XR_940498 NM_001128160 NP_001121632 NM_001128161 NP_001121633 NM_014517 NP_055332
|
| Function |
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. {ECO:0000250, ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:2006421, ECO:0000269|PubMed:8114710}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:8114710}.
|
| Tissue Specificity |
Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines. {ECO:0000269|PubMed:10644752}.
|