| Gene Symbol |
RITA1
|
| Entrez Gene |
84934
|
| Alt Symbol |
C12orf52, RITA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RBPJ interacting and tubulin associated 1
|
| Other Description |
RBPJ-interacting and tubulin-associated protein 1
|
| Swissprots |
C9JIN1 Q53GM3 B3KVZ4 Q96K30 Q96K25 F8VRG5
|
| Accessions |
CAC32398 CAE90924 EAW98041 EAW98042 Q96K30 AA594422 AK027733 BAB55328 AK027741 BAB55333 AK075358 BAC11568 AK123762 BAG53956 AK222908 BAD96628 AY007158 BC022092 AAH22092 BP212183 BX366456 DA207985 HQ447411 ADQ31897 XM_005253972 XP_005254029 NM_001286215 NP_001273144 NM_032848 NP_116237
|
| Function |
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. {ECO:0000269|PubMed:21102556}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21102556}. Nucleus {ECO:0000269|PubMed:21102556}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21102556}. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.
|