Gene Symbol | RITA1 |
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Entrez Gene | 84934 |
Alt Symbol | C12orf52, RITA |
Species | Human |
Gene Type | protein-coding |
Description | RBPJ interacting and tubulin associated 1 |
Other Description | RBPJ-interacting and tubulin-associated protein 1 |
Swissprots | C9JIN1 Q53GM3 B3KVZ4 Q96K30 Q96K25 F8VRG5 |
Accessions | CAC32398 CAE90924 EAW98041 EAW98042 Q96K30 AA594422 AK027733 BAB55328 AK027741 BAB55333 AK075358 BAC11568 AK123762 BAG53956 AK222908 BAD96628 AY007158 BC022092 AAH22092 BP212183 BX366456 DA207985 HQ447411 ADQ31897 XM_005253972 XP_005254029 NM_001286215 NP_001273144 NM_032848 NP_116237 |
Function | Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. {ECO:0000269|PubMed:21102556}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21102556}. Nucleus {ECO:0000269|PubMed:21102556}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21102556}. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear. |
C12orf52 (G-18) - sc-242022 from Santa Cruz Biotechnology
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C12orf52 (N-18) - sc-242020 from Santa Cruz Biotechnology
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C12orf52 (Y-18) - sc-242021 from Santa Cruz Biotechnology
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Anti-RITA antibody - ab201180 from Abcam
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Anti-RITA antibody - ab122531 from Abcam
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Anti-RITA antibody - N-terminal - ab170643 from Abcam
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Anti-RITA1 / C12orf52 Antibody (aa43-72, AP) - LS-C213316 from LifeSpan Bioscience
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Anti-RITA1 / C12orf52 Antibody (aa43-72, APC) - LS-C213319 from LifeSpan Bioscience
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Anti-RITA1 / C12orf52 Antibody (aa43-72, Biotin) - LS-C213320 from LifeSpan Bioscience
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Anti-RITA1 / C12orf52 Antibody (aa43-72, FITC) - LS-C213321 from LifeSpan Bioscience
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Anti-RITA1 / C12orf52 Antibody (aa43-72, PE) - LS-C213322 from LifeSpan Bioscience
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Anti-RITA1 / C12orf52 Antibody (aa43-72) - LS-C329380 from LifeSpan Bioscience
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Anti-RITA1 / C12orf52 Antibody (aa43-72, Azide-free, HRP) - LS-C213323 from LifeSpan Bioscience
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Anti-RITA1 / C12orf52 Antibody (aa44-72) - LS-C168800 from LifeSpan Bioscience
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RITA Antibody - NBP2-38441 from Novus Biologicals
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RITA Antibody - NBP1-94003 from Novus Biologicals
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RITA/C12orf52 Polyclonal Antibody - bs-11945R from Bioss
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RITA/C12orf52 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11945R-A350 from Bioss
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RITA/C12orf52 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11945R-A488 from Bioss
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RITA/C12orf52 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11945R-A555 from Bioss
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RITA/C12orf52 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11945R-A647 from Bioss
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RITA/C12orf52 Polyclonal Antibody, Cy3 Conjugated - bs-11945R-Cy3 from Bioss
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RITA/C12orf52 Polyclonal Antibody, Cy5 Conjugated - bs-11945R-Cy5 from Bioss
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RITA/C12orf52 Polyclonal Antibody, Cy5.5 Conjugated - bs-11945R-Cy5.5 from Bioss
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RITA/C12orf52 Polyclonal Antibody, Cy7 Conjugated - bs-11945R-Cy7 from Bioss
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