Gene Symbol | RITA1 |
---|---|
Entrez Gene | 84934 |
Alt Symbol | C12orf52, RITA |
Species | Human |
Gene Type | protein-coding |
Description | RBPJ interacting and tubulin associated 1 |
Other Description | RBPJ-interacting and tubulin-associated protein 1 |
Swissprots | C9JIN1 Q53GM3 B3KVZ4 Q96K30 Q96K25 F8VRG5 |
Accessions | CAC32398 CAE90924 EAW98041 EAW98042 Q96K30 AA594422 AK027733 BAB55328 AK027741 BAB55333 AK075358 BAC11568 AK123762 BAG53956 AK222908 BAD96628 AY007158 BC022092 AAH22092 BP212183 BX366456 DA207985 HQ447411 ADQ31897 XM_005253972 XP_005254029 NM_001286215 NP_001273144 NM_032848 NP_116237 |
Function | Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. {ECO:0000269|PubMed:21102556}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21102556}. Nucleus {ECO:0000269|PubMed:21102556}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21102556}. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear. |