| Gene Symbol |
GAS6
|
| Entrez Gene |
2621
|
| Alt Symbol |
AXLLG, AXSF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
growth arrest-specific 6
|
| Other Description |
AXL receptor tyrosine kinase ligand|AXL stimulatory factor|growth arrest-specific protein 6
|
| Swissprots |
E9PBL7 Q6IMN1 B3KVL4 B3KRQ7 Q7Z7N3 Q14393
|
| Accessions |
AAO41859 AAO84057 ABR09277 DAA01155 EAX09226 Q14393 AA045119 AK092028 BAG52469 AK122969 BAG53826 AK126533 BAC86580 AK129751 AK290803 BAF83492 AK303145 BAG64249 AL833761 CAH56234 BC030708 BC038984 AAH38984 BQ181504 BX380508 DB290970 HY038614 L13720 AAA58494 NM_000820 NP_000811 NM_001143945 NM_001143946
|
| Function |
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:18840707}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:9326369}.
|
| Tissue Specificity |
Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. {ECO:0000269|PubMed:8336730, ECO:0000269|PubMed:9326368}.
|
![Western Blot: GAS 6 Overexpression Lysate (Adult Normal) [NBL1-10974] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GAS 6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3882_GAS%25206%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10974-img0002.jpg)