Gene Symbol | GAS6 |
---|---|
Entrez Gene | 2621 |
Alt Symbol | AXLLG, AXSF |
Species | Human |
Gene Type | protein-coding |
Description | growth arrest-specific 6 |
Other Description | AXL receptor tyrosine kinase ligand|AXL stimulatory factor|growth arrest-specific protein 6 |
Swissprots | E9PBL7 Q6IMN1 B3KVL4 B3KRQ7 Q7Z7N3 Q14393 |
Accessions | AAO41859 AAO84057 ABR09277 DAA01155 EAX09226 Q14393 AA045119 AK092028 BAG52469 AK122969 BAG53826 AK126533 BAC86580 AK129751 AK290803 BAF83492 AK303145 BAG64249 AL833761 CAH56234 BC030708 BC038984 AAH38984 BQ181504 BX380508 DB290970 HY038614 L13720 AAA58494 NM_000820 NP_000811 NM_001143945 NM_001143946 |
Function | Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:18840707}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:9326369}. |
Tissue Specificity | Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. {ECO:0000269|PubMed:8336730, ECO:0000269|PubMed:9326368}. |