Gene Symbol | GAS6 |
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Entrez Gene | 2621 |
Alt Symbol | AXLLG, AXSF |
Species | Human |
Gene Type | protein-coding |
Description | growth arrest-specific 6 |
Other Description | AXL receptor tyrosine kinase ligand|AXL stimulatory factor|growth arrest-specific protein 6 |
Swissprots | E9PBL7 Q6IMN1 B3KVL4 B3KRQ7 Q7Z7N3 Q14393 |
Accessions | AAO41859 AAO84057 ABR09277 DAA01155 EAX09226 Q14393 AA045119 AK092028 BAG52469 AK122969 BAG53826 AK126533 BAC86580 AK129751 AK290803 BAF83492 AK303145 BAG64249 AL833761 CAH56234 BC030708 BC038984 AAH38984 BQ181504 BX380508 DB290970 HY038614 L13720 AAA58494 NM_000820 NP_000811 NM_001143945 NM_001143946 |
Function | Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:18840707}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:9326369}. |
Tissue Specificity | Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. {ECO:0000269|PubMed:8336730, ECO:0000269|PubMed:9326368}. |
Gas6 CRISPR/Cas9 KO Plasmid (h) - sc-400978 from Santa Cruz Biotechnology
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Gas6 HDR Plasmid (h) - sc-400978-HDR from Santa Cruz Biotechnology
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Gas6 Double Nickase Plasmid (h) - sc-400978-NIC from Santa Cruz Biotechnology
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Gas6 Double Nickase Plasmid (h2) - sc-400978-NIC-2 from Santa Cruz Biotechnology
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Gas6 CRISPR Activation Plasmid (h) - sc-400978-ACT from Santa Cruz Biotechnology
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Gas6 CRISPR Activation Plasmid (h2) - sc-400978-ACT-2 from Santa Cruz Biotechnology
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Gas6 Lentiviral Activation Particles (h) - sc-400978-LAC from Santa Cruz Biotechnology
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Gas6 Lentiviral Activation Particles (h2) - sc-400978-LAC-2 from Santa Cruz Biotechnology
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Gas6 siRNA (h) - sc-35450 from Santa Cruz Biotechnology
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Gas6 shRNA Plasmid (h) - sc-35450-SH from Santa Cruz Biotechnology
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Gas6 shRNA (h) Lentiviral Particles - sc-35450-V from Santa Cruz Biotechnology
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Gas6 RNAi - H00002621-R01 from Novus Biologicals
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MISSION® esiRNA - EHU077311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9142 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9142 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02186 from Sigma-Aldrich
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GAS6 siRNA (Human) - CRH1737 from Cohesion Biosciences
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GAS6 - MBS8240116 from MyBioSource
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Gas6 CRISPR/Cas9 KO Plasmid (h2) - sc-400978-KO-2 from Santa Cruz Biotechnology
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Gas6 HDR Plasmid (h2) - sc-400978-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human GAS6 (NM_000820.2) - SHH299478 from Creative biogene
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GAS6 shRNA Plasmid (Human) - CHH1737 from Cohesion Biosciences
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GAS6 miRNA 3'UTR clone - MiUTR3H-03377 from Creative biogene
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GAS6 miRNA 3'UTR clone - MiUTR3H-03378 from Creative biogene
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GAS6 miRNA 3'UTR clone - MiUTR3H-03379 from Creative biogene
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