Gene Symbol | GAS6 |
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Entrez Gene | 2621 |
Alt Symbol | AXLLG, AXSF |
Species | Human |
Gene Type | protein-coding |
Description | growth arrest-specific 6 |
Other Description | AXL receptor tyrosine kinase ligand|AXL stimulatory factor|growth arrest-specific protein 6 |
Swissprots | E9PBL7 Q6IMN1 B3KVL4 B3KRQ7 Q7Z7N3 Q14393 |
Accessions | AAO41859 AAO84057 ABR09277 DAA01155 EAX09226 Q14393 AA045119 AK092028 BAG52469 AK122969 BAG53826 AK126533 BAC86580 AK129751 AK290803 BAF83492 AK303145 BAG64249 AL833761 CAH56234 BC030708 BC038984 AAH38984 BQ181504 BX380508 DB290970 HY038614 L13720 AAA58494 NM_000820 NP_000811 NM_001143945 NM_001143946 |
Function | Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:18840707}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:9326369}. |
Tissue Specificity | Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. {ECO:0000269|PubMed:8336730, ECO:0000269|PubMed:9326368}. |
Human GAS 6 full length protein - ab131810 from Abcam
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Human GAS 6 peptide - ab97363 from Abcam
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Human GAS 6 protein fragment - ab114494 from Abcam
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Recombinant Human Gas6 Protein - H00002621-Q01 from Novus Biologicals
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Recombinant Human Gas6 Protein - H00002621-P01 from Novus Biologicals
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Recombinant Human Gas6, CF - 885-GS-050 from R&D Systems
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Human GAS6 Protein - abx066929 from Abbexa
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GAS6 / AXLLG - H00002621-P01-10 from Acris Antibodies
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GAS6 / AXLLG - H00002621-P01-25 from Acris Antibodies
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GAS6 / AXLLG - H00002621-Q01-10 from Acris Antibodies
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GAS6 / AXLLG - H00002621-Q01-25 from Acris Antibodies
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Growth Arrest Specific Protein 6 (GAS6), Human - 20-6415 from ARP American Research Products
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GAS6 Peptide - 8365P from ProSci
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GAS6 fusion protein - ag4617 from Proteintech Group
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GAS6 fusion protein - Ag5158 from Proteintech Group
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Recombinant Human GAS6 full-length, GST-tagged - GAS6-288TH from Creative Biomart
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Recombinant Human Growth Arrest-Specific 6, His-tagged - GAS6-613H from Creative Biomart
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Recombinant Human GAS6 (Ala31-Ala678), His-tagged - GAS6-622H from Creative Biomart
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Recombinant Human GAS6 - GAS6-28979TH from Creative Biomart
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Recombinant Human GAS6, His-tagged - GAS6-624H from Creative Biomart
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Recombinant Human GAS6 - GAS6-477H from Creative Biomart
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Recombinant Growth Arrest Specific Protein 6 (GAS6) - RPA204Hu01 from Uscn Life Science Inc.
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Recombinant Growth Arrest Specific Protein 6 (GAS6) - RPA204Mu01 from Uscn Life Science Inc.
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Recombinant Growth Arrest Specific Protein 6 (GAS6) - RPA204Mu02 from Uscn Life Science Inc.
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Recombinant Growth Arrest Specific Protein 6 (GAS6) - RPA204Ra01 from Uscn Life Science Inc.
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