| Gene Symbol |
RING1
|
| Entrez Gene |
6015
|
| Alt Symbol |
RING1A, RNF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 1
|
| Other Description |
E3 ubiquitin-protein ligase RING1|polycomb complex protein RING1|really interesting new gene 1 protein
|
| Swissprots |
A8JZZ0 Q06587 Q5JP96 Q86V19 Q5SQW2
|
| Accessions |
CAA20235 CAI95620 EAX03683 EAX03684 Q06587 AI828228 AK289355 BAF82044 AK297552 BAG59945 AK301010 BAG62627 AK301378 BAG62919 BC002922 AAH02922 BC051866 AAH51866 BI259576 BT007352 AAP36016 DQ892957 ABM83883 DQ896204 ABM87203 Z14000 CAA78389 NM_002931 NP_002922
|
| Function |
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:21282530}.
|
![Western Blot: RING1 Overexpression Lysate (Adult Normal) [NBL1-15372] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RING1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6320_RING1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15372-img0002.jpg)