RING1

Gene Symbol	RING1
Entrez Gene	6015
Alt Symbol	RING1A, RNF1
Species	Human
Gene Type	protein-coding
Description	ring finger protein 1
Other Description	E3 ubiquitin-protein ligase RING1\|polycomb complex protein RING1\|really interesting new gene 1 protein
Swissprots	A8JZZ0 Q06587 Q5JP96 Q86V19 Q5SQW2
Accessions	CAA20235 CAI95620 EAX03683 EAX03684 Q06587 AI828228 AK289355 BAF82044 AK297552 BAG59945 AK301010 BAG62627 AK301378 BAG62919 BC002922 AAH02922 BC051866 AAH51866 BI259576 BT007352 AAP36016 DQ892957 ABM83883 DQ896204 ABM87203 Z14000 CAA78389 NM_002931 NP_002922
Function	Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269\|PubMed:16359901}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:21282530}. Nucleus speckle {ECO:0000269\|PubMed:21282530}.

Ring1A (D2P4D) Rabbit mAb - 13069 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D2P4D

Western blot analysis of extracts from various cell lines using Ring1A (D2P4D) Rabbit mAb.

Ring1A Antibody - 2820 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of MOLT4 annd LNCaP cells using Ring1A Antibody.

RING1 (H-110) - sc-28736 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

RING1 (H-110): sc-28736. Western blot analysis of RING1 expression in non-transfected: sc-117752 (A) and mouse RING1 transfected: sc-123204 (B) 293T whole cell lysates.

RING1 (C-20) - sc-17267 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

RING1 (G-20) - sc-17265 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-RING1 antibody - ab102469 from Abcam

Prices	$376.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RING1 antibody (ab102469) at 1/3000 dilution + 293T whole cell lysate at 30 µg

Anti-RING1 antibody - ab76985 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-RING1 antibody (ab76985) at 5 µg/ml + immunogen at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-RING1 antibody - ab125193 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-RING1 antibody (ab125193) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-RING1 antibody - ab57985 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab57985 RING1 antibody at 1ug/ml.

Anti-RING1 antibody - ab98272 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RING1 antibody (ab98272) at 1 µg/ml (in 5% skim milk / PBS buffer) + COLO205 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-RING1 antibody [8C12F4] - ab175149 from Abcam

Prices	$384.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	8C12F4

Anti-RING1 antibody [8C12F4] (ab175149) at 1/500 dilution + RING1 recombinant protein

Anti-RING1 antibody [8E8A2] - ab181756 from Abcam

Prices	$384.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	8E8A2

All lanes : Anti-RING1 antibody [8E8A2] (ab181756) at 1/500 dilutionLane 1 : HEK293 cell lysate, non-transfectedLane 2 : HEK293 cell lysate, transfected with RING1 (aa 79-263)-hIgGFc

Anti-RING1 antibody [EPR13047] - ab180170 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR13047

All lanes : Anti-RING1 antibody [EPR13047] (ab180170) at 1/1000 dilutionLane 1 : Ramos cell lysateLane 2 : MOLT4 cell lysateLane 3 : LNCaP cell lysateLane 4 : HeLa cell lysateLane 5 : mouse NIH 3T3 cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labeled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-RING1 antibody - C-terminal - ab202388 from Abcam

Prices	$359.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-RING1 antibody - C-terminal (ab202388) at 1/1000 dilutionLane 1 : LNCaP cell lysateLane 2 : Rat H-4-II-E cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat anti-Rabbit IgG H&L (HRP) at 1/10000 dilution

Anti-RING1 antibody - ChIP Grade - ab32644 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-RING1 antibody - ChIP Grade (ab32644) at 1 µg/mlLane 1 : Human Kidney Whole Tissue LysateLane 2 : Human Liver Whole Tissue LysateLysates/proteins at 20 µg per lane.SecondaryIR Dye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-RING1 Antibody - LS-C131926 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RING1 Antibody - LS-C126230 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-RING1 Antibody (clone 2D5) - LS-C139530 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2D5

Anti-RING1 Antibody (N-Terminus) - LS-C30967 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RING1 Antibody (aa95-123, AP) - LS-C268265 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RING1 Antibody (aa95-123, APC) - LS-C268266 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RING1 Antibody (aa324-373) - LS-C110250 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

RING1 antibody LS-C110250 Western blot of HeLa lysate.

Anti-RING1 Antibody (aa215-264) - LS-C107934 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

RING1 antibody LS-C107934 Western blot of COLO205 cell lysate.

Anti-RING1 Antibody (aa95-123, Biotin) - LS-C268267 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RING1 Antibody (aa252-301) - LS-C109759 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

RING1 antibody LS-C109759 Western blot of Transfected 293T cell lysate.

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