RING1

Gene Symbol RING1
Entrez Gene 6015
Alt Symbol RING1A, RNF1
Species Human
Gene Type protein-coding
Description ring finger protein 1
Other Description E3 ubiquitin-protein ligase RING1|polycomb complex protein RING1|really interesting new gene 1 protein
Swissprots A8JZZ0 Q06587 Q5JP96 Q86V19 Q5SQW2
Accessions CAA20235 CAI95620 EAX03683 EAX03684 Q06587 AI828228 AK289355 BAF82044 AK297552 BAG59945 AK301010 BAG62627 AK301378 BAG62919 BC002922 AAH02922 BC051866 AAH51866 BI259576 BT007352 AAP36016 DQ892957 ABM83883 DQ896204 ABM87203 Z14000 CAA78389 NM_002931 NP_002922
Function Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.
Subcellular Location Nucleus {ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:21282530}.

RING1 CRISPR/Cas9 KO Plasmid (h) - sc-405198 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RING1 HDR Plasmid (h) - sc-405198-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RING1 Double Nickase Plasmid (h) - sc-405198-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RING1 Double Nickase Plasmid (h2) - sc-405198-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RING1 CRISPR Activation Plasmid (h) - sc-405198-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RING1 CRISPR Activation Plasmid (h2) - sc-405198-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RING1 Lentiviral Activation Particles (h) - sc-405198-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RING1 Lentiviral Activation Particles (h2) - sc-405198-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RING1 siRNA (h) - sc-38197 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RING1 shRNA Plasmid (h) - sc-38197-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RING1 shRNA (h) Lentiviral Particles - sc-38197-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RING1 RNAi - H00006015-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU230291 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18293 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18293 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02351 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02351

RING1 siRNA (Human) - CRH4081 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RING1 - MBS8227916 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RING1(NM_002931.3) - SHR182568 from Creative biogene

Category siRNA
Species Reactivities Human

RING1 shRNA Plasmid (Human) - CHH4081 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RING1 miRNA 3'UTR clone - MiUTR1H-08828 from Creative biogene

Species Reactivities Human
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