RING1

Gene Symbol	RING1
Entrez Gene	6015
Alt Symbol	RING1A, RNF1
Species	Human
Gene Type	protein-coding
Description	ring finger protein 1
Other Description	E3 ubiquitin-protein ligase RING1|polycomb complex protein RING1|really interesting new gene 1 protein
Swissprots	A8JZZ0 Q06587 Q5JP96 Q86V19 Q5SQW2
Accessions	CAA20235 CAI95620 EAX03683 EAX03684 Q06587 AI828228 AK289355 BAF82044 AK297552 BAG59945 AK301010 BAG62627 AK301378 BAG62919 BC002922 AAH02922 BC051866 AAH51866 BI259576 BT007352 AAP36016 DQ892957 ABM83883 DQ896204 ABM87203 Z14000 CAA78389 NM_002931 NP_002922
Function	Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:21282530}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RING1 full length protein - ab112348 from Abcam Category Protein Source Wheat germ Species Human

Human RING1 peptide - ab32805 from Abcam Category Peptide

Human RING1 peptide - ab32806 from Abcam Category Peptide

Human RING1 protein fragment - ab152656 from Abcam Category Protein Source Wheat germ Species Human

RING1 Antibody Blocking Peptide - LS-E3386 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RING1 Antibody Blocking Peptide - LS-E11715 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RING1 Antibody Blocking Peptide - LS-E11716 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RING1 Antibody Blocking Peptide - LS-E13721 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RING1 Antibody Blocking Peptide - LS-E13722 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RING1 Protein - H00006015-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RING1 Protein - H00006015-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RING1-Antibody-N-term-Blocking-Peptide - BP14560a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RING1 / RNF1 - H00006015-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RING1 / RNF1 - H00006015-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RING1 / RNF1 - H00006015-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RING1 / RNF1 - H00006015-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RING1 fusion protein - Ag6763 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human RING1 - RING1-29982TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human RING1, His-tagged - RING1-2311H from Creative Biomart Category Protein Source E.coli Species Human

RING1 / RNF1 - TP302650 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RING1 Recombinant Protein Antigen - NBP1-80830PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RING1-Antibody-C-term-Blocking-Peptide - BP2516b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RING1-Antibody-N-term-Blocking-Peptide - BP2516a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RING1-Blocking-Peptide-C-term - BP21001c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RING1 Peptide, Human - M34GP13316H from Creative Peptides Category Peptide Source Synthetic. Species Human

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