RING1

Gene Symbol	RING1
Entrez Gene	6015
Alt Symbol	RING1A, RNF1
Species	Human
Gene Type	protein-coding
Description	ring finger protein 1
Other Description	E3 ubiquitin-protein ligase RING1|polycomb complex protein RING1|really interesting new gene 1 protein
Swissprots	A8JZZ0 Q06587 Q5JP96 Q86V19 Q5SQW2
Accessions	CAA20235 CAI95620 EAX03683 EAX03684 Q06587 AI828228 AK289355 BAF82044 AK297552 BAG59945 AK301010 BAG62627 AK301378 BAG62919 BC002922 AAH02922 BC051866 AAH51866 BI259576 BT007352 AAP36016 DQ892957 ABM83883 DQ896204 ABM87203 Z14000 CAA78389 NM_002931 NP_002922
Function	Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:21282530}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ring1A Gene - orb145059 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human RING1 cDNA clone(NM_002931.3) - CDFH016342 from Creative Biomart Species Human Accession NM_002931.3

Human RING1 ORF Clone(NM_002931.3) - CDCR284444 from Creative Biomart Species Human Accession NM_002931.3

Human RING1 ORF Clone(NM_002931.3) - CDCR284445 from Creative Biomart Species Human Accession NM_002931.3

Human RING1 Gene ORF cDNA clone in cloning vector - HG14778-G from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, N-His tag - HG14778-NH from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14778-NF from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, C-His tag - HG14778-CH from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14778-ANG from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14778-CF from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14778-NM from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14778-CM from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid - HG14778-UT from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14778-CY from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14778-ACR from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14778-ANR from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14778-ACG from Sino Biological Species Human

Human RING1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14778-NY from Sino Biological Species Human

human RING1 ORF clone (NM_002931.3) - CDCH073968 from Creative biogene Species Human

Human RING1 ORF Clone (BC002922) - CDCS411049 from Creative biogene Species Human Accession Q06587

Human RING1 ORF clone (BC002922) - CDCB158793 from Creative biogene Species Human

Human RING1 cDNA Clone(NM_002931.3) - CDFH016342 from Creative biogene Species Human

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