Gene Symbol | Bcl2 |
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Entrez Gene | 12043 |
Alt Symbol | AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | B cell leukemia/lymphoma 2 |
Other Description | B-cell leukemia/lymphoma 2|apoptosis regulator Bcl-2 |
Swissprots | P10417 Q4VBF6 P10418 |
Accessions | AAA37281 AAA37282 EDL39861 EDL39862 P10417 AA867214 AK042257 AK049473 BAC33767 AK052879 AK076269 AK077913 AK155394 AK200702 AK219312 BB612176 BB662051 BC068988 AAH68988 BC095964 AAH95964 BQ887357 CD741269 CF736820 CJ106885 CJ161448 NM_009741 NP_033871 NM_177410 NP_803129 |
Function | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). |
Subcellular Location | Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. |
Tissue Specificity | Expressed in a variety of tissues. |
Top Pathways | Toxoplasmosis, MicroRNAs in cancer, Epstein-Barr virus infection, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway |
Bcl-2 (4C11) - sc-578 from Santa Cruz Biotechnology
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Bcl-2 (10C4) - sc-23960 from Santa Cruz Biotechnology
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Bcl-2 (YTH10C4) - sc-81002 from Santa Cruz Biotechnology
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Bcl-2 (5K140) - sc-70411 from Santa Cruz Biotechnology
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Bcl-2 Antibody (BCL/10C4) - NB100-78543 from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [DyLight 405LS] - NB100-78543V3 from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [DyLight 755] - NB100-78543IR from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [DyLight 680] - NB100-78543FR from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [Allophycocyanin] - NB100-78543APC from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [PerCP] - NB100-78543PCP from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [PE] - NB100-78543PE from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [DyLight 488] - NB100-78543G from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [7C] - NB100-78543V2 from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [DyLight 405] - NB100-78543V from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [DyLight 350] - NB100-78543UV from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [Alexa Fluor (R) 700] - NB100-78543AF700 from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [Alexa Fluor (R) 647] - NB100-78543AF647 from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [Alexa Fluor (R) 488] - NB100-78543AF488 from Novus Biologicals
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Bcl-2 Antibody (BCL/10C4) [Alexa Fluor (R) 405] - NB100-78543AF405 from Novus Biologicals
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Monoclonal Anti-Bcl-2 antibody produced in mouse - B9804 from Sigma-Aldrich
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Anti -BCL2 (Apoptosis Regulator Bcl-2) - B0003-46E1 from USBiological Life Science
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Anti -BCL2 (Apoptosis Regulator Bcl-2, B Cell CLL/lymphoma 2) - 139390 from USBiological Life Science
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Anti -BCL2 (Apoptosis Regulator Bcl-2, B Cell CLL/lymphoma 2) (AP) - 139390-AP from USBiological Life Science
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Anti -BCL2 (Apoptosis Regulator Bcl-2, B Cell CLL/lymphoma 2) (APC) - 139390-APC from USBiological Life Science
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Anti -BCL2 (Apoptosis Regulator Bcl-2, B Cell CLL/lymphoma 2) (Biotin) - 139390-Biotin from USBiological Life Science
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