| Gene Symbol |
Bcl2
|
| Entrez Gene |
12043
|
| Alt Symbol |
AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
B cell leukemia/lymphoma 2
|
| Other Description |
B-cell leukemia/lymphoma 2|apoptosis regulator Bcl-2
|
| Swissprots |
P10417 Q4VBF6 P10418
|
| Accessions |
AAA37281 AAA37282 EDL39861 EDL39862 P10417 AA867214 AK042257 AK049473 BAC33767 AK052879 AK076269 AK077913 AK155394 AK200702 AK219312 BB612176 BB662051 BC068988 AAH68988 BC095964 AAH95964 BQ887357 CD741269 CF736820 CJ106885 CJ161448 NM_009741 NP_033871 NM_177410 NP_803129
|
| Function |
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
|
| Subcellular Location |
Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Expressed in a variety of tissues.
|
| Top Pathways |
Toxoplasmosis, MicroRNAs in cancer, Epstein-Barr virus infection, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway
|