| Gene Symbol |
NIT2
|
| Entrez Gene |
56954
|
| Alt Symbol |
HEL-S-8a
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nitrilase family, member 2
|
| Other Description |
Nit protein 2|epididymis secretory sperm binding protein Li 8a|nitrilase homolog 2|omega-amidase NIT2
|
| Swissprots |
Q9NQR4 B2R9A3 Q8WUF0 D3DN47
|
| Accessions |
EAW79824 EAW79825 Q9NQR4 AF260334 AAG44665 AF284574 AAF87103 AK225979 AK294010 BAG57372 AK295835 BAH12195 AK313704 BAG36450 BC020620 AAH20620 BC107890 AAI07891 BM748852 DB466042 DQ893135 ABM84061 DQ896416 ABM87415 FJ224326 ACI46018 NM_020202 NP_064587
|
| Function |
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle. {ECO:0000269|PubMed:17488281, ECO:0000269|PubMed:19595734}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17488281}.
|
| Tissue Specificity |
Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine and colon. {ECO:0000269|PubMed:14528910, ECO:0000269|PubMed:17488281}.
|
| Top Pathways |
Alanine, aspartate and glutamate metabolism
|