FFAR4

Gene Symbol FFAR4
Entrez Gene 338557
Alt Symbol BMIQ10, GPR120, GPR129, GT01, O3FAR1, PGR4
Species Human
Gene Type protein-coding
Description free fatty acid receptor 4
Other Description G-protein coupled receptor 120|G-protein coupled receptor 129|G-protein coupled receptor GT01|G-protein coupled receptor PGR4|omega-3 fatty acid receptor 1
Swissprots Q5VY26 Q495H1 Q5NUL3 Q86SM7 Q7Z605 Q5VY25
Accessions EAW50069 EAW50070 Q5NUL3 AB115768 BAD83368 AI469384 AI732606 AK301525 BAG63028 AY255573 AAO85085 AY288417 AAP72126 BC101175 AAI01176 BM757151 BX647721 DA986310 XM_011539746 XP_011538048 NM_001195755 NP_001182684 NM_181745 NP_859529
Function Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation. {ECO:0000269|PubMed:15619630}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalized with ARRB2 following DHA treatment. {ECO:0000250}.
Tissue Specificity Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas. {ECO:0000269|PubMed:15619630, ECO:0000269|PubMed:17250804}.

GPR120 (G-18) - sc-48201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GPR120 (H-10) - sc-390752 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GPR120 (H-10): sc-390752. Western blot analysis of GPR120 expression in HeLa (A) and Du 145 (B) whole cell lysates.

GPR120 (H-155) - sc-99105 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GPR120 (H-155): sc-99105. Western blot analysis of GPR120 expression in HeLa (A) and DU 145 (B) whole cell lysates.

GPR120 (N-14) - sc-48203 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GPCR GPR120 antibody - ab97272 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GPCR GPR120 antibody (ab97272) at 1/2000 dilution + HeLa whole cell lysate at 30 µg

Anti-GPCR GPR120 antibody - ab118757 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPCR GPR120 antibody (ab118757) at 1 µg/ml + HepG2 cell lysate at 10 µg

Anti-GPCR GPR120 antibody - ab129867 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GPCR GPR120 antibody (ab129867) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-GPCR GPR120 antibody - C-terminal - ab188954 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human small intestine (enterocytes) tissue, labeling GPCR GPR120 with ab188954 at 8 µg/ml.

Anti-O3FAR1 / GPR120 Antibody (aa263-275) - LS-C112741 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-O3FAR1 / GPR120 Antibody (C-Terminus) IHC-plus™ - LS-A2006 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-O3FAR1 / GPR120 antibody LS-A2006 IHC of human small intestine, enterocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-O3FAR1 / GPR120 Antibody (Transmembrane Domain) IHC-plus™ - LS-A2004 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-O3FAR1 / GPR120 antibody LS-A2004 IHC of human colon, crypts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-O3FAR1 / GPR120 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A2005 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-O3FAR1 / GPR120 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-O3FAR1 / GPR120 Antibody (aa243-292) - LS-C145840 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
O3FAR1 / GPR120 antibody LS-C145840 Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.

Anti-O3FAR1 / GPR120 Antibody (aa231-260, AP) - LS-C235894 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-O3FAR1 / GPR120 Antibody (aa231-260, APC) - LS-C235895 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-O3FAR1 / GPR120 Antibody (aa231-260, Biotin) - LS-C235896 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-O3FAR1 / GPR120 Antibody (aa231-260, FITC) - LS-C235897 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-O3FAR1 / GPR120 Antibody (aa231-260, PE) - LS-C235898 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-O3FAR1 / GPR120 Antibody (aa231-260, Azide-free, HRP) - LS-C249114 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-O3FAR1 / GPR120 Antibody (aa230-260) - LS-C321732 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-O3FAR1 / GPR120 Antibody (aa28-40) - LS-C204275 from LifeSpan Bioscience

Prices $345.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Western blot with GPR120 antibody. Lane 1: MW markers, Lane 2: LoVo cell lysate, Lane 3: LoVo cell lysate + immunizing peptide (10 ug/ml).

Anti-O3FAR1 / GPR120 Antibody (aa231-260) - LS-C166619 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GPR120 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The GPR120 antibody detected the GPR120 protein (arrow).

Anti-O3FAR1 / GPR120 Antibody (N-Terminus) IHC-plus™ - LS-A2003 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-O3FAR1 / GPR120 antibody LS-A2003 IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-O3FAR1 / GPR120 Antibody (aa247-258) IHC-plus™ - LS-B9793 from LifeSpan Bioscience

Prices $395.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Anti-O3FAR1 / GPR120 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9793 dilution 1:50.

Anti-O3FAR1 / GPR120 Antibody (aa1-71) IHC-plus™ - LS-B9386 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-O3FAR1 / GPR120 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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