| Gene Symbol |
FFAR4
|
| Entrez Gene |
338557
|
| Alt Symbol |
BMIQ10, GPR120, GPR129, GT01, O3FAR1, PGR4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
free fatty acid receptor 4
|
| Other Description |
G-protein coupled receptor 120|G-protein coupled receptor 129|G-protein coupled receptor GT01|G-protein coupled receptor PGR4|omega-3 fatty acid receptor 1
|
| Swissprots |
Q5VY26 Q495H1 Q5NUL3 Q86SM7 Q7Z605 Q5VY25
|
| Accessions |
EAW50069 EAW50070 Q5NUL3 AB115768 BAD83368 AI469384 AI732606 AK301525 BAG63028 AY255573 AAO85085 AY288417 AAP72126 BC101175 AAI01176 BM757151 BX647721 DA986310 XM_011539746 XP_011538048 NM_001195755 NP_001182684 NM_181745 NP_859529
|
| Function |
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation. {ECO:0000269|PubMed:15619630}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalized with ARRB2 following DHA treatment. {ECO:0000250}.
|
| Tissue Specificity |
Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas. {ECO:0000269|PubMed:15619630, ECO:0000269|PubMed:17250804}.
|