FFAR4

Gene Symbol FFAR4
Entrez Gene 338557
Alt Symbol BMIQ10, GPR120, GPR129, GT01, O3FAR1, PGR4
Species Human
Gene Type protein-coding
Description free fatty acid receptor 4
Other Description G-protein coupled receptor 120|G-protein coupled receptor 129|G-protein coupled receptor GT01|G-protein coupled receptor PGR4|omega-3 fatty acid receptor 1
Swissprots Q5VY26 Q495H1 Q5NUL3 Q86SM7 Q7Z605 Q5VY25
Accessions EAW50069 EAW50070 Q5NUL3 AB115768 BAD83368 AI469384 AI732606 AK301525 BAG63028 AY255573 AAO85085 AY288417 AAP72126 BC101175 AAI01176 BM757151 BX647721 DA986310 XM_011539746 XP_011538048 NM_001195755 NP_001182684 NM_181745 NP_859529
Function Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation. {ECO:0000269|PubMed:15619630}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalized with ARRB2 following DHA treatment. {ECO:0000250}.
Tissue Specificity Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas. {ECO:0000269|PubMed:15619630, ECO:0000269|PubMed:17250804}.

GPR120 CRISPR/Cas9 KO Plasmid (h) - sc-401362 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR120 HDR Plasmid (h) - sc-401362-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR120 Double Nickase Plasmid (h) - sc-401362-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR120 Double Nickase Plasmid (h2) - sc-401362-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR120 CRISPR Activation Plasmid (h) - sc-401362-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR120 CRISPR Activation Plasmid (h2) - sc-401362-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR120 Lentiviral Activation Particles (h) - sc-401362-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR120 Lentiviral Activation Particles (h2) - sc-401362-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR120 siRNA (h) - sc-60737 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR120 shRNA Plasmid (h) - sc-60737-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR120 shRNA (h) Lentiviral Particles - sc-60737-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN9550 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9550 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FFAR4 siRNA (Human) - CRJ7241 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FFAR4 - MBS8240401 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GPR120 CRISPR/Cas9 KO Plasmid (h2) - sc-401362-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR120 HDR Plasmid (h2) - sc-401362-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human O3FAR1 (NM_181745.3) - SHH356880 from Creative biogene

Category siRNA
Species Reactivities Human

FFAR4 shRNA Plasmid (Human) - CHJ7241 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

O3FAR1 miRNA 3'UTR clone - MiUTR4H-TG03953 from Creative biogene

Species Reactivities Human
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