PDK2

Gene Symbol	PDK2
Entrez Gene	5164
Alt Symbol	PDHK2, PDKII
Species	Human
Gene Type	protein-coding
Description	pyruvate dehydrogenase kinase, isozyme 2
Other Description	PDH kinase 2|[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 2|pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
Swissprots	A8K3A7 Q6P515 Q15119 Q9BS05 B3KNW0
Accessions	EAW94642 EAW94643 EAW94644 Q15119 AK055119 BAG51472 AK290522 BAF83211 AK293600 BAG57064 AK297089 BAG59604 AW302405 AW469593 BC005811 AAH05811 BC040478 AAH40478 BC063137 AAH63137 BQ024783 BQ071206 DA199055 JF432702 ADZ15919 L42451 AAC42010 NM_001199898 NP_001186827 NM_001199899 NP_001186828 NM_001199900 NP_001186829 NM_002611 NP_002602
Function	Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. {ECO:0000269
Subcellular Location	Mitochondrion matrix.
Tissue Specificity	Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. {ECO:0000269|PubMed:7499431}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS2024755 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.061ng/mL. Range 0.156-10ng/mL

ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) - SED464Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse PDK2 ELISA Kit (Sandwich ELISA) - LS-F25423 from LifeSpan Bioscience Category ELISA Kit Prices $800.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 0.156-10 ng/ml

Human PDK2 ELISA Kit - E093122 from Biobool Category ELISA Kit

anti-PDK2 antibody - ARG55699 from Arigo Biolaboratories Category ELISA Kit

anti-PDK2 antibody - ARG55666 from Arigo Biolaboratories Category ELISA Kit

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9354509 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9367420 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9364167 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9354438 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9362606 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9360976 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9345504 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9346085 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9360456 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9344416 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9345964 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9365769 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9367182 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9357681 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9354643 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9364941 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9351555 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2), ELISA Kit - MBS9349694 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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