PDK2

Gene Symbol	PDK2
Entrez Gene	5164
Alt Symbol	PDHK2, PDKII
Species	Human
Gene Type	protein-coding
Description	pyruvate dehydrogenase kinase, isozyme 2
Other Description	PDH kinase 2|[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 2|pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
Swissprots	A8K3A7 Q6P515 Q15119 Q9BS05 B3KNW0
Accessions	EAW94642 EAW94643 EAW94644 Q15119 AK055119 BAG51472 AK290522 BAF83211 AK293600 BAG57064 AK297089 BAG59604 AW302405 AW469593 BC005811 AAH05811 BC040478 AAH40478 BC063137 AAH63137 BQ024783 BQ071206 DA199055 JF432702 ADZ15919 L42451 AAC42010 NM_001199898 NP_001186827 NM_001199899 NP_001186828 NM_001199900 NP_001186829 NM_002611 NP_002602
Function	Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. {ECO:0000269
Subcellular Location	Mitochondrion matrix.
Tissue Specificity	Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. {ECO:0000269|PubMed:7499431}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PDK2 full length protein - ab125592 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Recombinant PDK2 (human), active - ab110354 from Abcam Source E. coli Species Human

PDK2 Antibody Blocking Peptide - LS-E2950 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK2 Antibody Blocking Peptide - LS-E11091 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK2 Antibody Blocking Peptide - LS-E8630 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PDK2 Protein - H00005164-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PDK2 Protein - H00005164-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PDK2 Peptide - P2130 from Novus Biologicals Category Peptide Species Human

PDK2-Antibody-C-term-Blocking-Peptide - BP7039b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDK2 Blocking Peptide - 33R-2541 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDK2 - H00005164-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDK2 - H00005164-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDK2 - H00005164-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDK2 - H00005164-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDK2 - P5616 from Acris Antibodies Category Protein Prices $790.00 Sizes 5 µg Species Human

PDK2 fusion protein - Ag8206 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PDK2 fusion protein - ag8183 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PDK2, His-tagged - PDK2-651H from Creative Biomart Category Protein Source Bacteria.

Recombinant Human PDK2, His-tagged - PDK2-29162TH from Creative Biomart Category Protein

Recombinant Human PDK2, His-tagged - PDK2-1620H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PDK2, GST-tagged - PDK2-1071H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) - RPD464Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

PDK2 (R291) Peptide - BS3913P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial(PDK2) ,partial - CSB-YP618976HU CSB-EP618976HU CSB-BP618976HU CSB-MP618976HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PDK2 Blocking Peptide - abx161700 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey

Search more