PDK2

Gene Symbol	PDK2
Entrez Gene	5164
Alt Symbol	PDHK2, PDKII
Species	Human
Gene Type	protein-coding
Description	pyruvate dehydrogenase kinase, isozyme 2
Other Description	PDH kinase 2|[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 2|pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
Swissprots	A8K3A7 Q6P515 Q15119 Q9BS05 B3KNW0
Accessions	EAW94642 EAW94643 EAW94644 Q15119 AK055119 BAG51472 AK290522 BAF83211 AK293600 BAG57064 AK297089 BAG59604 AW302405 AW469593 BC005811 AAH05811 BC040478 AAH40478 BC063137 AAH63137 BQ024783 BQ071206 DA199055 JF432702 ADZ15919 L42451 AAC42010 NM_001199898 NP_001186827 NM_001199899 NP_001186828 NM_001199900 NP_001186829 NM_002611 NP_002602
Function	Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. {ECO:0000269
Subcellular Location	Mitochondrion matrix.
Tissue Specificity	Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. {ECO:0000269|PubMed:7499431}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDK2 CRISPR/Cas9 KO Plasmid (h) - sc-416916 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PDK2 HDR Plasmid (h) - sc-416916-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PDK2 Double Nickase Plasmid (h) - sc-416916-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PDK2 Double Nickase Plasmid (h2) - sc-416916-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PDK2 CRISPR Activation Plasmid (h) - sc-416916-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PDK2 CRISPR Activation Plasmid (h2) - sc-416916-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PDK2 Lentiviral Activation Particles (h) - sc-416916-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PDK2 Lentiviral Activation Particles (h2) - sc-416916-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PDK2 siRNA (h) - sc-39027 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PDK2 shRNA Plasmid (h) - sc-39027-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PDK2 shRNA (h) Lentiviral Particles - sc-39027-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PDK2 RNAi - H00005164-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PDK2 RNAi - H00005164-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU028791 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU101181 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1556 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1557 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1558 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN16566 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16566 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PDK2 siRNA (Human) - CRH3444 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PDK2 (NM_002611.4) - SHH372876 from Creative biogene Category siRNA Species Reactivities Human

PDK2 shRNA Plasmid (Human) - CHH3444 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PDK2 miRNA 3'UTR clone - MiUTR1H-07745 from Creative biogene Species Reactivities Human

PDK2 miRNA 3'UTR clone - MiUTR1H-07746 from Creative biogene Species Reactivities Human

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