PDK2

Gene Symbol	PDK2
Entrez Gene	5164
Alt Symbol	PDHK2, PDKII
Species	Human
Gene Type	protein-coding
Description	pyruvate dehydrogenase kinase, isozyme 2
Other Description	PDH kinase 2|[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 2|pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
Swissprots	A8K3A7 Q6P515 Q15119 Q9BS05 B3KNW0
Accessions	EAW94642 EAW94643 EAW94644 Q15119 AK055119 BAG51472 AK290522 BAF83211 AK293600 BAG57064 AK297089 BAG59604 AW302405 AW469593 BC005811 AAH05811 BC040478 AAH40478 BC063137 AAH63137 BQ024783 BQ071206 DA199055 JF432702 ADZ15919 L42451 AAC42010 NM_001199898 NP_001186827 NM_001199899 NP_001186828 NM_001199900 NP_001186829 NM_002611 NP_002602
Function	Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. {ECO:0000269
Subcellular Location	Mitochondrion matrix.
Tissue Specificity	Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. {ECO:0000269|PubMed:7499431}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDK2 (D-20) - sc-14486 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PDK2 (N-20) - sc-14484 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PDK2 (S-15) - sc-100534 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-PDK2 antibody - ab87243 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PDK2 antibody - ab55575 from Abcam Prices $378.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-PDK2 antibody - ab172065 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-PDK2 antibody - ab103429 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PDK2 antibody [3F2D7] - ab201964 from Abcam Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F2D7

Anti-PDK2 antibody [EP1947Y] - ab76152 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP1947Y

Anti-PDK2 antibody [EPR1948Y] - ab68164 from Abcam Prices $381.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1948Y

Anti-PDK2 Antibody (Arg291) - LS-C192127 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PDK2 Antibody (clone 180CT10.2.3, AP) - LS-C206346 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 180CT10.2.3

Anti-PDK2 Antibody (aa260-309) - LS-C120281 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PDK2 Antibody (N-Terminus, clone EPR1948Y) - LS-C105278 from LifeSpan Bioscience Prices $480.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1948Y

Anti-PDK2 Antibody (clone 180CT10.2.3, APC) - LS-C206347 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 180CT10.2.3

Anti-PDK2 Antibody (aa242-291) - LS-C200471 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PDK2 Antibody (N-Terminus, clone EP1947Y) - LS-C50065 from LifeSpan Bioscience Prices $485.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP1947Y

Anti-PDK2 Antibody (clone 180CT10.2.3, FITC) - LS-C206350 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 180CT10.2.3

Anti-PDK2 Antibody (clone 180CT10.2.3, Biotin) - LS-C206351 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 180CT10.2.3

Anti-PDK2 Antibody (clone 180CT10.2.3, PE) - LS-C206352 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 180CT10.2.3

Anti-PDK2 Antibody (clone 180CT10.2.3, Azide-free, HRP) - LS-C206988 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 180CT10.2.3

Anti-PDK2 Antibody (FITC) - LS-C207429 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDK2 Antibody (Azide-free, HRP) - LS-C207430 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDK2 Antibody (PE) - LS-C207431 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDK2 Antibody (aa378-407, AP) - LS-C207432 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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