| Gene Symbol | PDK2 |
|---|---|
| Entrez Gene | 5164 |
| Alt Symbol | PDHK2, PDKII |
| Species | Human |
| Gene Type | protein-coding |
| Description | pyruvate dehydrogenase kinase, isozyme 2 |
| Other Description | PDH kinase 2|[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 2|pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial |
| Swissprots | A8K3A7 Q6P515 Q15119 Q9BS05 B3KNW0 |
| Accessions | EAW94642 EAW94643 EAW94644 Q15119 AK055119 BAG51472 AK290522 BAF83211 AK293600 BAG57064 AK297089 BAG59604 AW302405 AW469593 BC005811 AAH05811 BC040478 AAH40478 BC063137 AAH63137 BQ024783 BQ071206 DA199055 JF432702 ADZ15919 L42451 AAC42010 NM_001199898 NP_001186827 NM_001199899 NP_001186828 NM_001199900 NP_001186829 NM_002611 NP_002602 |
| Function | Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. {ECO:0000269 |
| Subcellular Location | Mitochondrion matrix. |
| Tissue Specificity | Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. {ECO:0000269|PubMed:7499431}. |