TAB2

Gene Symbol TAB2
Entrez Gene 23118
Alt Symbol CHTD2, MAP3K7IP2, TAB-2
Species Human
Gene Type protein-coding
Description TGF-beta activated kinase 1/MAP3K7 binding protein 2
Other Description TAK1-binding protein 2|TGF-beta-activated kinase 1 and MAP3K7-binding protein 2|mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Swissprots Q9NYJ8 Q9UFP7 B2RCC4 O94838 E1P5A0 Q76N06 Q6I9W8
Accessions ABC40736 EAW47805 EAW47806 EAW47807 Q9NYJ8 AB018276 BAA34453 AF241230 AAF67176 AI159838 AK025538 AK295750 BAG58581 AK307650 AK315038 BAG37521 AL050180 AL117407 CAB55907 BC035910 AAH35910 BC041998 BM661637 BX645362 CR457387 CAG33668 DA154923 DB467477 HG499787 HG499788 XM_006715403 XP_006715466 XM_011535633 XP_011533935 XM_011535634 XP_011533936 NM_001292034 NP_001278963 NM_001292035 NP_001278964 NM_015093 NP_055908 NR_125861 NM_145342
Function Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:20493459}.
Subcellular Location Membrane {ECO:0000269|PubMed:10882101}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Cytoplasm, cytosol {ECO:0000269|PubMed:10882101}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol.
Tissue Specificity Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:20493459}.
Top Pathways Osteoclast differentiation, TNF signaling pathway, Epstein-Barr virus infection, Herpes simplex infection, Measles

Phospho-TAB2 (Ser372) (D5A4) Rabbit mAb - 8155 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5A4
Western blot analysis of extracts from 293T cells, untreated or treated with Human Interleukin-1β (hIL-1β) #8900 (50 ng/ml) and Calyculin A (Serine/Threonine Phosphatase Inhibitor) #9902 (CalA) (100 nM, 20 min), using Phospho-TAB2 (Ser372) (D5A4) Rabbit mAb (upper) or total TAB2 (C88H10) Rabbit mAb #3745 (lower). Lysates were then treated with a combination of calf intestinal phosphatase (CIP) and λ-phosphatase to show phospho-specificity.

TAB2 (C88H10) Rabbit mAb - 3745 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C88H10
Western blot analysis of extracts from Raji, A20 and C6 cell lines using TAB2 (C88H10) Rabbit mAb.

TAB2 Antibody - 3744 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts SNB19, Raji and A20 cell lines using TAB2 Antibody.

TAB2 (E-5) - sc-398188 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TAB2 (E-5): sc-398188. Western blot analysis of TAB2 expression in non-transfected: sc-117752 (A) and mouse TAB2 transfected: sc-123889 (B) 293T whole cell lysates.

TAB2 (E-20) - sc-11850 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TAB2 (E-20): sc-11850. Western blot analysis of TAB2 expression in non-transfected: sc-117752 (A) and mouse TAB2 transfected: sc-123889 (B) 293T whole cell lysates.

TAB2 (H-300) - sc-20756 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TAB2 (H-300): sc-20756. Western blot analysis of TAB2 expression in non-transfected: sc-117752 (A) and mouse TAB2 transfected: sc-123889 (B) 293T whole cell lysates.

TAB2 (K-20) - sc-11851 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TAB2 (K-20): sc-11851. Immunofluorescence staining of methanol-fixed A-431 cells (A) and immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor (B) showing cytoplasmic staining.

Anti-TAB2 antibody - ab172412 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-TAB2 antibody (ab172412) at 1 µg/mlLane 1 : TAB2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-TAB2 antibody - ab118485 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab118485 at 7.5&microg/ml staining TAB2 in Formalin-fixed, Paraffin-embedded Human colon tissue by immunohistochemistry.

Anti-TAB2 antibody - ab118532 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of TAB2 expression in Formalin-Fixed, Paraffin-Embedded Human Colon tissue using 7.5 µg/ml ab118532.

Anti-TAB2 antibody - ab153882 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TAB2 antibody (ab153882) at 1/500 dilution + NIH3T3 whole cell lysate at 30 µg

Anti-TAB2 antibody - ab115845 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Thymus (formalin-fixed, paraffin-embedded) stained with ab115845 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-TAB2 antibody - ab140201 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue labelling TAB2 with ab140201 at 5 µg/ml.

Anti-TAB2 antibody [3B5] - ab130252 from Abcam

Host Mouse
Clonality Monoclonal
Clone 3B5
All lanes : Anti-TAB2 antibody [3B5] (ab130252) at 1/500 dilutionLane 1 : HEK293 cell lysateLane 2 : TAB2-hIgGFc transfected HEK293 cell lysate

Anti-TAB2 Antibody (aa300-350) - LS-C289470 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TAB2 Antibody (aa500-550) - LS-C289471 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TAB2 Antibody - LS-C153238 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TAB2 Antibody (Internal) - LS-C345742 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of TAB2 Antibody with human 786-0 Whole Cell lysate.

Anti-TAB2 Antibody (clone 3B5) - LS-C169273 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B5
Western blot using TAB2 monoclonal antibody against HEK293 (1) and TAB2(AA: 1-300)-hIgGFc transfected HEK293 (2) cell lysate.

Anti-TAB2 Antibody (aa79-90) IHC-plus™ - LS-B5139 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-TAB2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5139 concentration 3.75 ug/ml.

Anti-TAB2 Antibody (aa161-173) IHC-plus™ - LS-B5140 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-TAB2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5140 concentration 3.75 ug/ml.

Anti-TAB2 Antibody (N-Terminus) - LS-C29682 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TAB2 antibody LS-C29682 was used in IHC to stain formalin-fixed, paraffin-embedded human stomach.

Anti-TAB2 Antibody (C-Terminus) IHC-plus™ - LS-B4704 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TAB2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4704 concentration 5 ug/ml.

Anti-TAB2 Antibody (aa487-506) - LS-C313381 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
TAB2 antibody. IHC(P): Human Breast Cancer Tissue.

TAB2 Antibody - NBP1-46200 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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