TAB2

Gene Symbol	TAB2
Entrez Gene	23118
Alt Symbol	CHTD2, MAP3K7IP2, TAB-2
Species	Human
Gene Type	protein-coding
Description	TGF-beta activated kinase 1/MAP3K7 binding protein 2
Other Description	TAK1-binding protein 2|TGF-beta-activated kinase 1 and MAP3K7-binding protein 2|mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Swissprots	Q9NYJ8 Q9UFP7 B2RCC4 O94838 E1P5A0 Q76N06 Q6I9W8
Accessions	ABC40736 EAW47805 EAW47806 EAW47807 Q9NYJ8 AB018276 BAA34453 AF241230 AAF67176 AI159838 AK025538 AK295750 BAG58581 AK307650 AK315038 BAG37521 AL050180 AL117407 CAB55907 BC035910 AAH35910 BC041998 BM661637 BX645362 CR457387 CAG33668 DA154923 DB467477 HG499787 HG499788 XM_006715403 XP_006715466 XM_011535633 XP_011533935 XM_011535634 XP_011533936 NM_001292034 NP_001278963 NM_001292035 NP_001278964 NM_015093 NP_055908 NR_125861 NM_145342
Function	Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:20493459}.
Subcellular Location	Membrane {ECO:0000269|PubMed:10882101}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Cytoplasm, cytosol {ECO:0000269|PubMed:10882101}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol.
Tissue Specificity	Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:20493459}.
Top Pathways	Osteoclast differentiation, TNF signaling pathway, Epstein-Barr virus infection, Herpes simplex infection, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TAB2 Antibody Blocking Peptide - LS-E30090 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TAB2 Antibody Blocking Peptide - LS-E27320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TAB2 Antibody Blocking Peptide - LS-E11346 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TAB2 / MAP3K7IP2 (C-term) Control Peptide - AP55459CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TAB2 Peptide - 3389P from ProSci Category Peptide Species Human

MAP3K7IP2 fusion protein - Ag5742 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MAP3K7IP2 fusion protein - Ag5917 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human MAP3K7IP2, GST-tagged - MAP3K7IP2-736H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2(TAB2) - CSB-YP868358HU CSB-EP868358HU CSB-BP868358HU CSB-MP868358HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2), Recombinant Protein - MBS1457635 from MyBioSource Category Protein Prices $1,500.00, $1,500.00, $1,725.00, $1,725.00, $2,560.00, $2,560.00, $3,005.00, $3,005.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

TAB2-Blocking-Peptide-C-term - BP21381b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TAB2 Peptide, Human - M34GP15524H from Creative Peptides Category Peptide Source Synthetic. Species Human

TAB2 Recombinant Protein Antigen - NBP2-56607PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human TAB2 Protein (401-693 aa), His-Myc-tagged - TAB2-2769H from Creative Biomart Category Protein Source Baculovirus Species Human

Recombinant Human TAB2 Protein, His-tagged - TAB2-374H from Creative Biomart Category Protein Source Bacteria Species Human

Recombinant Human TAB2 Protein, GST-tagged - TAB2-375H from Creative Biomart Category Protein Source Bacteria Species Human

Search more