TAB2

Gene Symbol TAB2
Entrez Gene 23118
Alt Symbol CHTD2, MAP3K7IP2, TAB-2
Species Human
Gene Type protein-coding
Description TGF-beta activated kinase 1/MAP3K7 binding protein 2
Other Description TAK1-binding protein 2|TGF-beta-activated kinase 1 and MAP3K7-binding protein 2|mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Swissprots Q9NYJ8 Q9UFP7 B2RCC4 O94838 E1P5A0 Q76N06 Q6I9W8
Accessions ABC40736 EAW47805 EAW47806 EAW47807 Q9NYJ8 AB018276 BAA34453 AF241230 AAF67176 AI159838 AK025538 AK295750 BAG58581 AK307650 AK315038 BAG37521 AL050180 AL117407 CAB55907 BC035910 AAH35910 BC041998 BM661637 BX645362 CR457387 CAG33668 DA154923 DB467477 HG499787 HG499788 XM_006715403 XP_006715466 XM_011535633 XP_011533935 XM_011535634 XP_011533936 NM_001292034 NP_001278963 NM_001292035 NP_001278964 NM_015093 NP_055908 NR_125861 NM_145342
Function Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:20493459}.
Subcellular Location Membrane {ECO:0000269|PubMed:10882101}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Cytoplasm, cytosol {ECO:0000269|PubMed:10882101}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol.
Tissue Specificity Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:20493459}.
Top Pathways Osteoclast differentiation, TNF signaling pathway, Epstein-Barr virus infection, Herpes simplex infection, Measles

TAB2 CRISPR/Cas9 KO Plasmid (h) - sc-401596 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TAB2 HDR Plasmid (h) - sc-401596-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TAB2 Double Nickase Plasmid (h) - sc-401596-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TAB2 Double Nickase Plasmid (h2) - sc-401596-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TAB2 CRISPR Activation Plasmid (h) - sc-401596-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TAB2 CRISPR Activation Plasmid (h2) - sc-401596-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TAB2 Lentiviral Activation Particles (h) - sc-401596-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TAB2 Lentiviral Activation Particles (h2) - sc-401596-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TAB2 siRNA (h) - sc-41049 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TAB2 shRNA Plasmid (h) - sc-41049-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TAB2 shRNA (h) Lentiviral Particles - sc-41049-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU069151 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20944 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20944 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TAB2 siRNA (Human) - CRH8011 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TAB2 - MBS8203965 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TAB2 (NM_015093.4) - SHH422364 from Creative biogene

Category siRNA
Species Reactivities Human

Human TAB2 siRNA - orb268513 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TAB2 shRNA Plasmid (Human) - CHH8011 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TAB2 miRNA 3'UTR clone - MiUTR3H-07374 from Creative biogene

Species Reactivities Human
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