TAB2

Gene Symbol TAB2
Entrez Gene 23118
Alt Symbol CHTD2, MAP3K7IP2, TAB-2
Species Human
Gene Type protein-coding
Description TGF-beta activated kinase 1/MAP3K7 binding protein 2
Other Description TAK1-binding protein 2|TGF-beta-activated kinase 1 and MAP3K7-binding protein 2|mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Swissprots Q9NYJ8 Q9UFP7 B2RCC4 O94838 E1P5A0 Q76N06 Q6I9W8
Accessions ABC40736 EAW47805 EAW47806 EAW47807 Q9NYJ8 AB018276 BAA34453 AF241230 AAF67176 AI159838 AK025538 AK295750 BAG58581 AK307650 AK315038 BAG37521 AL050180 AL117407 CAB55907 BC035910 AAH35910 BC041998 BM661637 BX645362 CR457387 CAG33668 DA154923 DB467477 HG499787 HG499788 XM_006715403 XP_006715466 XM_011535633 XP_011533935 XM_011535634 XP_011533936 NM_001292034 NP_001278963 NM_001292035 NP_001278964 NM_015093 NP_055908 NR_125861 NM_145342
Function Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:20493459}.
Subcellular Location Membrane {ECO:0000269|PubMed:10882101}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Cytoplasm, cytosol {ECO:0000269|PubMed:10882101}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol.
Tissue Specificity Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:20493459}.
Top Pathways Osteoclast differentiation, TNF signaling pathway, Epstein-Barr virus infection, Herpes simplex infection, Measles

Human TAB2 ELISA Kit (Sandwich ELISA) - LS-F12690 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 15.6
Range 15.6-1000 pg/ml

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, TAB2, Human, ELISA Kit - E2882h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 15.6-1000 pg/mL

mitogen-activated protein kinase kinase kinase 7 interacting protein 2, ELISA Kit - MBS9332195 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rat TAB2 ELISA Kit (Custom ELISA) - LS-F19805 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 15.6-1000 pg/ml

Mouse TAB2 ELISA Kit (Custom ELISA) - LS-F19806 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 15.6-1000 pg/ml

TAB2 - EKH4490 from Nordic BioSite

Sensitivity 9.375pg/ml
Range 15.6-1000pg/ml

TAB2 ELISA Kit (Human) : 96 Wells (OKEH01678) - OKEH01678 from Aviva Systems Biology

Category ELISA Kit
Prices $420.00
Sizes 96 wells
Sensitivity < 10 pg/mL
Range 15.6 - 1000 pg/mL

Human MAP3K7IP2 ELISA Kit - E024753 from Biobool

Category ELISA Kit

Human TAB2 ELISA Kit - E037934 from Biobool

Category ELISA Kit

Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 ELISA Kit - EK4554 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Sensitivity less than 32pg/mL
Range 78-5000 pg/mL

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, ELISA Kit - MBS2883593 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 15.6-1000 pg/mL

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, ELISA Kit - MBS9428380 from MyBioSource

Category ELISA Kit
Prices $555.00
Sizes 96 tests
Sensitivity Less than 10pg/mL
Range 15.6-1000 pg/mL

Human TAB2 ELISA Kit (Sandwich ELISA) - LS-F33837 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 9.375
Range 15.6-1000 pg/ml
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