TAB2

Gene Symbol	TAB2
Entrez Gene	23118
Alt Symbol	CHTD2, MAP3K7IP2, TAB-2
Species	Human
Gene Type	protein-coding
Description	TGF-beta activated kinase 1/MAP3K7 binding protein 2
Other Description	TAK1-binding protein 2|TGF-beta-activated kinase 1 and MAP3K7-binding protein 2|mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Swissprots	Q9NYJ8 Q9UFP7 B2RCC4 O94838 E1P5A0 Q76N06 Q6I9W8
Accessions	ABC40736 EAW47805 EAW47806 EAW47807 Q9NYJ8 AB018276 BAA34453 AF241230 AAF67176 AI159838 AK025538 AK295750 BAG58581 AK307650 AK315038 BAG37521 AL050180 AL117407 CAB55907 BC035910 AAH35910 BC041998 BM661637 BX645362 CR457387 CAG33668 DA154923 DB467477 HG499787 HG499788 XM_006715403 XP_006715466 XM_011535633 XP_011533935 XM_011535634 XP_011533936 NM_001292034 NP_001278963 NM_001292035 NP_001278964 NM_015093 NP_055908 NR_125861 NM_145342
Function	Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:20493459}.
Subcellular Location	Membrane {ECO:0000269|PubMed:10882101}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Cytoplasm, cytosol {ECO:0000269|PubMed:10882101}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol.
Tissue Specificity	Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:20493459}.
Top Pathways	Osteoclast differentiation, TNF signaling pathway, Epstein-Barr virus infection, Herpes simplex infection, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAP3K7IP2 293T Cell Transient Overexpression Lysate(Denatured) - H00023118-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

TAB2 293 Cell Lysate - 402108 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TAB2 Overexpression Lysate (Native) - NBL1-12857 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TAB2 Over-expression Lysate Product - GWB-6BE684 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

TAB2 Overexpression Lysate (Denatured) - H00023118-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human TAB2 Knockdown Stable Cell Line - CSC-DC015524 from Creative biogene Category Cell Line Species Human

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