Gene Symbol | DHFRL1 |
---|---|
Entrez Gene | 200895 |
Alt Symbol | DHFRP4 |
Species | Human |
Gene Type | protein-coding |
Description | dihydrofolate reductase-like 1 |
Other Description | dihydrofolate reductase pseudogene 4|dihydrofolate reductase, mitochondrial|dihydrofolate reductase-like protein 1 |
Swissprots | Q6P4I9 D3DN30 Q86XF0 |
Accessions | EAW79895 EAW79896 Q86XF0 AK122674 BAG53658 AL832912 CAH10617 AW104373 BC045541 AAH45541 BC063379 AAH63379 HQ447989 ADQ32471 XM_011512537 XP_011510839 NM_001195643 NP_001182572 NM_176815 NP_789785 |
Function | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. {ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188}. |
Subcellular Location | Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane. |
Tissue Specificity | Expressed in numerous cell lines. {ECO:0000269|PubMed:21876184}. |
Top Pathways | Folate biosynthesis, One carbon pool by folate |