Gene Symbol | DHFRL1 |
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Entrez Gene | 200895 |
Alt Symbol | DHFRP4 |
Species | Human |
Gene Type | protein-coding |
Description | dihydrofolate reductase-like 1 |
Other Description | dihydrofolate reductase pseudogene 4|dihydrofolate reductase, mitochondrial|dihydrofolate reductase-like protein 1 |
Swissprots | Q6P4I9 D3DN30 Q86XF0 |
Accessions | EAW79895 EAW79896 Q86XF0 AK122674 BAG53658 AL832912 CAH10617 AW104373 BC045541 AAH45541 BC063379 AAH63379 HQ447989 ADQ32471 XM_011512537 XP_011510839 NM_001195643 NP_001182572 NM_176815 NP_789785 |
Function | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. {ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188}. |
Subcellular Location | Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane. |
Tissue Specificity | Expressed in numerous cell lines. {ECO:0000269|PubMed:21876184}. |
Top Pathways | Folate biosynthesis, One carbon pool by folate |
Anti-DHFRL1 antibody - ab171837 from Abcam
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Anti-DHFRL1 antibody - ab197258 from Abcam
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Anti-DHFRL1 antibody - ab103891 from Abcam
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Anti-DHFRL1 Antibody (aa45-74, AP) - LS-C234550 from LifeSpan Bioscience
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Anti-DHFRL1 Antibody (aa71-120) - LS-C111506 from LifeSpan Bioscience
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Anti-DHFRL1 Antibody (aa45-74, Biotin) - LS-C234553 from LifeSpan Bioscience
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Anti-DHFRL1 Antibody (aa45-74, APC) - LS-C234552 from LifeSpan Bioscience
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Anti-DHFRL1 Antibody (aa45-74, FITC) - LS-C234554 from LifeSpan Bioscience
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Anti-DHFRL1 Antibody (aa45-74, PE) - LS-C234555 from LifeSpan Bioscience
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Anti-DHFRL1 Antibody (aa45-74, Azide-free, HRP) - LS-C249823 from LifeSpan Bioscience
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Anti-DHFRL1 Antibody (aa44-74) - LS-C320824 from LifeSpan Bioscience
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Anti-DHFRL1 Antibody (aa45-74) - LS-C167391 from LifeSpan Bioscience
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Anti-DHFRL1 Antibody (aa4-185, clone 1E2) - LS-C337442 from LifeSpan Bioscience
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DHFRL1 Antibody (1E2) - NBP2-01019 from Novus Biologicals
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DHFRL1 Antibody - NBP2-33268 from Novus Biologicals
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DHFRL1 Antibody - NBP1-55510 from Novus Biologicals
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DHFRL1 Antibody - H00200895-B01P from Novus Biologicals
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Anti-DHFRL1 antibody produced in mouse - SAB1408972 from Sigma-Aldrich
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Anti-DHFRL1 antibody produced in rabbit - HPA051465 from Sigma-Aldrich
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ANTI-DHFRL1 (CENTER) antibody produced in rabbit - SAB1303280 from Sigma-Aldrich
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Anti-DHFRL1 antibody produced in rabbit - SAB2105903 from Sigma-Aldrich
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DHFRL1 antibody - middle region (ARP53341_P050) - ARP53341_P050 from Aviva Systems Biology
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DHFRL1-Antibody-Center - AP13364c from Abgent, a WuXi AppTec company
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DHFRL1 antibody, Internal - GTX45554 from GeneTex
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DHFRL1 Antibody - middle region (OAAB09680) - OAAB09680 from Aviva Systems Biology
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