| Gene Symbol |
PHF8
|
| Entrez Gene |
23133
|
| Alt Symbol |
JHDM1F, MRXSSD, ZNF422
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PHD finger protein 8
|
| Other Description |
histone lysine demethylase PHF8|jumonji C domain-containing histone demethylase 1F
|
| Swissprots |
Q7Z6D4 Q9HAH2 Q5JPS3 Q5JPS0 Q5JPR9 Q5VUJ4 Q5JPS2 Q5H9U5 Q9UPP1 B3KMV4 B7Z911
|
| Accessions |
EAW93167 EAW93168 EAW93169 EAW93170 Q9UPP1 AB029034 BAA83063 AF091081 AAC72950 AK021696 BAB13877 AK022788 BAG51116 AK027229 AK304272 BAH14147 BC017720 BC042108 BC053861 AAH53861 BE676640 CR933612 CAI45929 DA458639 DB079048 XM_005261996 XP_005262053 XM_005261997 XP_005262054 XM_005261999 XP_005262056 XM_005262000 XP_005262057 XM_006724585 XP_006724648 XM_011530778 XP_011529080 NM_001184896 NP_001171825 NM_001184897 NP_001171826 NM_001184898 NP_001171827 NM_015107 NP_055922
|
| Function |
Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Note=Recruited to H3K4me3 sites on chromatin during interphase. Dissociates from chromatin when cells enter mitosis.
|