PHF8

Gene Symbol	PHF8
Entrez Gene	23133
Alt Symbol	JHDM1F, MRXSSD, ZNF422
Species	Human
Gene Type	protein-coding
Description	PHD finger protein 8
Other Description	histone lysine demethylase PHF8|jumonji C domain-containing histone demethylase 1F
Swissprots	Q7Z6D4 Q9HAH2 Q5JPS3 Q5JPS0 Q5JPR9 Q5VUJ4 Q5JPS2 Q5H9U5 Q9UPP1 B3KMV4 B7Z911
Accessions	EAW93167 EAW93168 EAW93169 EAW93170 Q9UPP1 AB029034 BAA83063 AF091081 AAC72950 AK021696 BAB13877 AK022788 BAG51116 AK027229 AK304272 BAH14147 BC017720 BC042108 BC053861 AAH53861 BE676640 CR933612 CAI45929 DA458639 DB079048 XM_005261996 XP_005262053 XM_005261997 XP_005262054 XM_005261999 XP_005262056 XM_005262000 XP_005262057 XM_006724585 XP_006724648 XM_011530778 XP_011529080 NM_001184896 NP_001171825 NM_001184897 NP_001171826 NM_001184898 NP_001171827 NM_015107 NP_055922
Function	Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in
Subcellular Location	Nucleus. Nucleus, nucleolus. Note=Recruited to H3K4me3 sites on chromatin during interphase. Dissociates from chromatin when cells enter mitosis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PHF8 peptide - ab36066 from Abcam Category Peptide

Human PHF8 protein fragment - ab196430 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

PHF8-Antibody-C-term-Blocking-peptide - BP12259b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PHF8-Antibody-C-term-Blocking-Peptide - BP9276b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant PHF8-l protein - 31462 from ActiveMotif Category Protein Prices $425.00 Sizes 20 µg Source E. coli Species Human

Recombinant PHF8-s protein - 31461 from ActiveMotif Category Protein Prices $425.00 Sizes 20 µg Source E. coli Species Human

Recombinant PHF8 protein - 31435 from ActiveMotif Category Protein Prices $395.00 Sizes 20 μg Source Baculovirus Species Human

Recombinant Human PHF8, FLAG-tagged - PHF8-61H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human PHF8, GST-tagged - PHF8-62H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human PHF8, GST-tagged - PHF8-63H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant PHD Finger Protein 8 (PHF8) - RPH375Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant PHD Finger Protein 8 (PHF8) - RPH375Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human Histone lysine demethylase PHF8(PHF8) ,partial - CSB-YP892365HU CSB-EP892365HU CSB-BP892365HU CSB-MP892365HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PHF8 Recombinant Protein Antigen - NBP1-83079PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PHF8-Blocking-Peptide-N-term - BP1041a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PHF8 Peptide, Human - M34GP11704H from Creative Peptides Category Peptide Source Synthetic. Species Human

PHF8 Recombinant Protein Antigen - NBP2-56147PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Histone lysine demethylase PHF8 (PHF8), partial, Recombinant Protein - MBS1473181 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PHD Finger Protein 8, Recombinant Protein - MBS2033131 from MyBioSource Category Protein Prices $170.00, $345.00, $535.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

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