IL36A

Gene Symbol	IL36A
Entrez Gene	27179
Alt Symbol	FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6
Species	Human
Gene Type	protein-coding
Description	interleukin 36, alpha
Other Description	FIL1 epsilon|IL-1 epsilon|IL-1F6 (FIL-1-epsilon)|interleukin 1 family, member 6 (epsilon)|interleukin 1, epsilon|interleukin-1 epsilon|interleukin-1 family member 6|interleukin-36 alpha
Swissprots	Q53SR7 Q9UHA7 Q7RTZ8 B2RAD9 Q5BLR4
Accessions	AAX20113 AAY14988 CAD29875 EAW73614 Q9UHA7 AF201831 AAF25211 AK314149 BAG36836 BC107042 AAI07043 BC107043 AAI07044 XM_005263639 XP_005263696 XM_011510965 XP_011509267 NM_014440 NP_055255
Function	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by u
Subcellular Location	Secreted {ECO:0000305}.
Tissue Specificity	Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin. {ECO:0000269|PubMed:11466363}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL36A ELISA Kit (Sandwich ELISA) - LS-F9627 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 2.7 pg/ml Range 0.819-200 ng/ml

Human IL36A ELISA Kit (Sandwich ELISA) - LS-F11791 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.819-200 ng/ml

Human IL36A / Interleukin-36 Alpha ELISA Kit - RAB0686 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Custom Human IL-1F6 ELISA Kit - orb158955 from Biorbyt Category ELISA Kit Prices $740.00, $1,258.00, $2,678.00 Sizes 96 well, 192 assays, 480 assays

Interleukin 1 Epsilon (IL1e), Human, ELISA Kit - SEE843Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 5.1pg/mL Range 15.6-1,000pg/mL

Interleukin-36 alpha, IL36A, Human, ELISA Kit - E2010h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Interleukin 1 Epsilon (IL1e), Human, CLIA Kit - SCE843Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 6.3pg/mL Range 15.6-1,000pg/mL

Human IL-1 F6 ELISA - ELH-IL1F6 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 0.8 ng/ml Range 0.8 ng/ml - 200 ng/ml

Interleukin 36, ELISA Kit - MBS755459 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 36, ELISA Kit - MBS751115 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 36, ELISA Kit - MBS748110 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 36, ELISA Kit - MBS744796 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 36, ELISA Kit - MBS754539 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 36, ELISA Kit - MBS755062 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Interleukin 36, ELISA Kit - MBS755606 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Interleukin 36, ELISA Kit - MBS750241 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL

Interleukin 36, ELISA Kit - MBS749737 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 36, ELISA Kit - MBS744627 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 36, ELISA Kit - MBS748498 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 36, ELISA Kit - MBS748263 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

interleukin 1 family, member 6 (epsilon) , ELISA Kit - MBS928580 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human IL1F6 is typically less than 3.9 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 15.6 pg/ml -1000 pg/ml.

interleukin 1 family, member 6 (epsilon) , ELISA Kit - MBS706936 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 3.9 pg/ml. Range 15.6 pg/ml -1000 pg/ml.

interleukin 1 family, member 6 (epsilon) , ELISA Kit - MBS706763 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Interleukin 1 Epsilon (IL1e) - SEE843Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 3.0pg/mL. Range 7.81-500pg/mL The standard curve concentrations used for the ELISA’s were 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.63pg/mL, 7.81pg/mL

CLIA Kit for Interleukin 1 Epsilon (IL1e) - SCE843Hu from Uscn Life Science Inc. Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.6pg/mL. Range 1.37-1000pg/mL The standard curve concentrations used for the CLIA’s were 1000pg/mL, 333.33pg/mL, 111.11pg/mL, 37.04pg/mL, 12.35pg/mL, 4.12pg/mL, 1.37pg/mL

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