IL36A

Gene Symbol	IL36A
Entrez Gene	27179
Alt Symbol	FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6
Species	Human
Gene Type	protein-coding
Description	interleukin 36, alpha
Other Description	FIL1 epsilon|IL-1 epsilon|IL-1F6 (FIL-1-epsilon)|interleukin 1 family, member 6 (epsilon)|interleukin 1, epsilon|interleukin-1 epsilon|interleukin-1 family member 6|interleukin-36 alpha
Swissprots	Q53SR7 Q9UHA7 Q7RTZ8 B2RAD9 Q5BLR4
Accessions	AAX20113 AAY14988 CAD29875 EAW73614 Q9UHA7 AF201831 AAF25211 AK314149 BAG36836 BC107042 AAI07043 BC107043 AAI07044 XM_005263639 XP_005263696 XM_011510965 XP_011509267 NM_014440 NP_055255
Function	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by u
Subcellular Location	Secreted {ECO:0000305}.
Tissue Specificity	Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin. {ECO:0000269|PubMed:11466363}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL1F6-Over-expression-Lysate - LY10383a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

IL1F6 293T Cell Transient Overexpression Lysate(Denatured) - H00027179-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

IL36A overexpression lysate - LY415288 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IL1F6 293 Cell Lysate - 407204 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

IL1F6 Over-expression Lysate Product - GWB-182A36 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

IL1F6 Overexpression Lysate (Native) - NBP2-10323 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

IL1F6 Overexpression Lysate (Denatured) - H00027179-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human IL36A Knockdown Stable Cell Line - CSC-DC007599 from Creative biogene Category Cell Line Species Human

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