IL36A

Gene Symbol	IL36A
Entrez Gene	27179
Alt Symbol	FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6
Species	Human
Gene Type	protein-coding
Description	interleukin 36, alpha
Other Description	FIL1 epsilon|IL-1 epsilon|IL-1F6 (FIL-1-epsilon)|interleukin 1 family, member 6 (epsilon)|interleukin 1, epsilon|interleukin-1 epsilon|interleukin-1 family member 6|interleukin-36 alpha
Swissprots	Q53SR7 Q9UHA7 Q7RTZ8 B2RAD9 Q5BLR4
Accessions	AAX20113 AAY14988 CAD29875 EAW73614 Q9UHA7 AF201831 AAF25211 AK314149 BAG36836 BC107042 AAI07043 BC107043 AAI07044 XM_005263639 XP_005263696 XM_011510965 XP_011509267 NM_014440 NP_055255
Function	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by u
Subcellular Location	Secreted {ECO:0000305}.
Tissue Specificity	Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin. {ECO:0000269|PubMed:11466363}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL36 alpha full length protein - ab151822 from Abcam Category Protein Source E. coli Species Human

Human IL36 alpha full length protein - ab153289 from Abcam Category Protein Source Wheat germ Species Human

Human IL36 alpha full length protein - ab193744 from Abcam Category Protein Source Mammalian Species Human

Human IL36 alpha protein fragment - ab153290 from Abcam Category Protein Source Wheat germ Species Human

IL36A Antibody Blocking Peptide - LS-E7785 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL36A Blocking Peptide - LS-E22814 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IL-36 alpha/IL-1F6 Protein - NBP2-34876 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Human

Recombinant Human IL-36 alpha/IL-1F6 Protein - NBP2-34880 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Human

Recombinant Human IL1F6 Protein - H00027179-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IL1F6 Recombinant Protein - H00027179-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IL1F6-Antibody-Center-Blocking-peptide - BP5234c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) - 6995-IL-010 from R&D Systems Category Protein Source E. coli-derived, Lys6-Phe158

Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158), CF - 6995-IL-010/CF from R&D Systems Category Protein Source E. coli-derived, Lys6-Phe158

Recombinant Human IL-36 alpha/IL-1F6 - 1078-IL-025 from R&D Systems Category Protein Source E. coli-derived, Met1-Phe158

Recombinant Human IL-36 alpha/IL-1F6, CF - 1078-IL-025/CF from R&D Systems Category Protein Source E. coli-derived, Met1-Phe158

Human IL36A protein - orb168599 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human IL1F6 protein - orb139147 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 10 μg, 20 μg Source E. coli Species Human

Human IL1F6 protein (Native) - orb139145 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source E. coli Species Human

Human IL1F6 protein (His Tag) - orb139146 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source E. coli Species Human

Mouse IL36A protein - orb168600 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

Human IL1F6 protein - orb49478 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

IL1F6 / IL1E - H00027179-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IL1F6 / IL1E - H00027179-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

IL1F6 / IL1E - H00027179-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IL1F6 / IL1E - H00027179-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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