IL36A

Gene Symbol	IL36A
Entrez Gene	27179
Alt Symbol	FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6
Species	Human
Gene Type	protein-coding
Description	interleukin 36, alpha
Other Description	FIL1 epsilon|IL-1 epsilon|IL-1F6 (FIL-1-epsilon)|interleukin 1 family, member 6 (epsilon)|interleukin 1, epsilon|interleukin-1 epsilon|interleukin-1 family member 6|interleukin-36 alpha
Swissprots	Q53SR7 Q9UHA7 Q7RTZ8 B2RAD9 Q5BLR4
Accessions	AAX20113 AAY14988 CAD29875 EAW73614 Q9UHA7 AF201831 AAF25211 AK314149 BAG36836 BC107042 AAI07043 BC107043 AAI07044 XM_005263639 XP_005263696 XM_011510965 XP_011509267 NM_014440 NP_055255
Function	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by u
Subcellular Location	Secreted {ECO:0000305}.
Tissue Specificity	Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin. {ECO:0000269|PubMed:11466363}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL-1F6 (H-60) - sc-368235 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

IL-1F6 (N-15) - sc-51302 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

IL-1F6 (V-16) - sc-51305 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-IL36 alpha antibody - ab116279 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IL36 alpha antibody - ab104085 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-IL36 alpha antibody - ab69414 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-IL36 alpha antibody [3A12] - ab117925 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3A12

Anti-IL36 alpha antibody [MM0385-3C55] - ab90932 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone MM0385-3C55

Anti-IL36 alpha antibody - C-terminal - ab180909 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IL36A Antibody (APC) - LS-C36981 from LifeSpan Bioscience Prices $545.00 Sizes 100 tst Host Rat Clonality Monoclonal

Anti-IL36A Antibody (N-Terminus) - LS-C155166 from LifeSpan Bioscience Prices $245.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-IL36A Antibody (aa43-73, APC) - LS-C236553 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-IL36A Antibody (aa43-73, AP) - LS-C236552 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-IL36A Antibody (aa43-73, Biotin) - LS-C236554 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-IL36A Antibody (aa43-73, FITC) - LS-C236555 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-IL36A Antibody (aa43-73, Azide-free, HRP) - LS-C249261 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-IL36A Antibody - LS-C308457 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-IL36A Antibody (aa43-73, PE) - LS-C236557 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-IL36A Antibody (aa43-73) - LS-C322212 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-IL36A Antibody (clone 3A12) - LS-C115415 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3A12

Anti-IL36A Antibody (aa35-61) - LS-C165187 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-IL36A Antibody (clone 3A2) - LS-C115439 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3A2

Anti-IL36A Antibody (C-Terminus) - LS-C201140 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

IL-36 alpha/IL-1F6 Antibody [Unconjugated] - AF1078 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

IL1F6 Antibody (1A4) - NBP2-02758 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1A4

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