| Gene Symbol | IL36A |
|---|---|
| Entrez Gene | 27179 |
| Alt Symbol | FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 36, alpha |
| Other Description | FIL1 epsilon|IL-1 epsilon|IL-1F6 (FIL-1-epsilon)|interleukin 1 family, member 6 (epsilon)|interleukin 1, epsilon|interleukin-1 epsilon|interleukin-1 family member 6|interleukin-36 alpha |
| Swissprots | Q53SR7 Q9UHA7 Q7RTZ8 B2RAD9 Q5BLR4 |
| Accessions | AAX20113 AAY14988 CAD29875 EAW73614 Q9UHA7 AF201831 AAF25211 AK314149 BAG36836 BC107042 AAI07043 BC107043 AAI07044 XM_005263639 XP_005263696 XM_011510965 XP_011509267 NM_014440 NP_055255 |
| Function | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by u |
| Subcellular Location | Secreted {ECO:0000305}. |
| Tissue Specificity | Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin. {ECO:0000269|PubMed:11466363}. |