| Gene Symbol |
DYRK1B
|
| Entrez Gene |
9149
|
| Alt Symbol |
AOMS3, MIRK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
|
| Other Description |
dual specificity tyrosine-phosphorylation-regulated kinase 1B|minibrain-related kinase|mirk protein kinase
|
| Swissprots |
O75789 Q9Y463 O75258 O75788
|
| Accessions |
AAC28914 EAW56916 EAW56917 EAW56918 EAW56919 EAW56920 EAW56921 EAW56922 EAW56923 EAW56924 Q9Y463 AF205861 AAF15893 AK074971 BAG52042 AK302127 BAG63504 BC009688 BC018751 AAH18751 BC025291 AAH25291 BI964831 BQ446787 DQ892536 ABM83462 DQ895747 ABM86673 HY024135 Y17999 CAA76989 XM_005259395 XP_005259452 XM_005259398 XP_005259455 XM_011527469 XP_011525771 XM_011527470 XP_011525772 XM_011548813 XP_011547115 XM_011548814 XP_011547116 XM_011548815 XP_011547117 XM_011548816 XP_011547118 NM_004714 NP_004705 NM_006483 NP_006474 NM_006484 NP_006475
|
| Function |
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC). {ECO:0000269|PubMed:10910078, ECO:0000269|PubMed:11980910, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:24827035}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. {ECO:0000269|PubMed:10910078}.
|