NR0B2

Gene Symbol NR0B2
Entrez Gene 8431
Alt Symbol SHP, SHP1
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 0, group B, member 2
Other Description nuclear receptor SHP|nuclear receptor subfamily 0 group B member 2|orphan nuclear receptor SHP|small heterodimer partner
Swissprots Q5QP36 F1D8P5 Q15466
Accessions AAC41998 BAB68530 EAX07781 Q15466 AA872285 AI457167 AK310048 BC030207 AAH30207 DA930064 HQ692833 ADZ17344 XM_011542297 XP_011540599 NM_021969 NP_068804
Function Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. {ECO:0000269|PubMed:14752053}.
Subcellular Location Nucleus {ECO:0000269|PubMed:14752053}. Cytoplasm {ECO:0000269|PubMed:14752053}. Note=Colocalizes with NEUROD1 in the nucleus.
Tissue Specificity Liver. Low levels of expression were detected in heart and pancreas. {ECO:0000269|PubMed:8650544}.
Top Pathways Bile secretion

SHP (A-7) - sc-271470 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SHP (A-7): sc-271470. Western blot analysis of SHP expression in non-transfected: sc-117752 (A) and human SHP transfected: sc-114141 (B) 293T whole cell lysates.

SHP (D-17) - sc-23057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SHP (F-12) - sc-271469 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SHP (F-12): sc-271469. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

SHP (H-160) - sc-30169 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SHP (H-160): sc-30169. Western blot analysis of SHP expression in non-transfected: sc-117752 (A) and human SHP transfected: sc-114141 (B) 293T whole cell lysates.

SHP (H-5) - sc-271511 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SHP (H-5): sc-271511. Western blot analysis of SHP expression in non-transfected: sc-117752 (A) and human SHP transfected: sc-114141 (B) 293T whole cell lysates.

SHP (Q-14) - sc-15283 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SHP (Q-14): sc-15283. Western blot analysis of SHP expression in A-431 nuclear extract.

Anti-NR0B2 antibody - ab186874 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat lung tissue labelling NR0B2 with ab186874 at 1/100. Magnification: 400x.

Anti-NR0B2 antibody - ab96605 from Abcam

Prices $304.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-NR0B2 antibody (ab96605) at 1/1000 dilution + Molt-4 whole cell lysate at 30 µg

Anti-NR0B2 antibody - ab172133 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-NR0B2 antibody (ab172133) at 1 µg/mlLane 1 : NR0B2 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-NR0B2 antibody [N7519] - ab41947 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone N7519

Anti-NR0B2 Antibody - LS-C9361 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µg
Host Rat
Clonality Monoclonal

Anti-NR0B2 Antibody - LS-C331719 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat brain using NR0B2 antibody at dilution of 1:100 (400x lens).

Anti-NR0B2 Antibody (aa110-159) IHC-plus™ - LS-B3560 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NR0B2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3560 concentration 5 ug/ml.

Anti-NR0B2 Antibody (aa56-83, AP) - LS-C238161 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR0B2 Antibody (aa56-83, APC) - LS-C238162 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR0B2 Antibody (aa56-83, Biotin) - LS-C238163 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR0B2 Antibody (aa56-83, FITC) - LS-C238164 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR0B2 Antibody (aa182-231) - LS-C80144 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-NR0B2 Antibody (aa146-195) - LS-C80143 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-NR0B2 Antibody (N-Terminus) - LS-C80745 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-NR0B2 Antibody (aa56-83, Azide-free, HRP) - LS-C248950 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR0B2 Antibody (aa56-83, PE) - LS-C238168 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR0B2 Antibody (Ligand-binding Domain) IHC-plus™ - LS-A5411 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NR0B2 antibody LS-A5411 IHC of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-NR0B2 Antibody (aa56-83) - LS-C323430 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR0B2 Antibody - LS-C341357 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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