NR0B2

Gene Symbol NR0B2
Entrez Gene 8431
Alt Symbol SHP, SHP1
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 0, group B, member 2
Other Description nuclear receptor SHP|nuclear receptor subfamily 0 group B member 2|orphan nuclear receptor SHP|small heterodimer partner
Swissprots Q5QP36 F1D8P5 Q15466
Accessions AAC41998 BAB68530 EAX07781 Q15466 AA872285 AI457167 AK310048 BC030207 AAH30207 DA930064 HQ692833 ADZ17344 XM_011542297 XP_011540599 NM_021969 NP_068804
Function Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. {ECO:0000269|PubMed:14752053}.
Subcellular Location Nucleus {ECO:0000269|PubMed:14752053}. Cytoplasm {ECO:0000269|PubMed:14752053}. Note=Colocalizes with NEUROD1 in the nucleus.
Tissue Specificity Liver. Low levels of expression were detected in heart and pancreas. {ECO:0000269|PubMed:8650544}.
Top Pathways Bile secretion

SHP CRISPR/Cas9 KO Plasmid (h) - sc-400964 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHP HDR Plasmid (h) - sc-400964-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHP Double Nickase Plasmid (h) - sc-400964-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHP Double Nickase Plasmid (h2) - sc-400964-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHP CRISPR Activation Plasmid (h) - sc-400964-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHP CRISPR Activation Plasmid (h2) - sc-400964-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHP Lentiviral Activation Particles (h) - sc-400964-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHP Lentiviral Activation Particles (h2) - sc-400964-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHP siRNA (h) - sc-44101 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SHP shRNA Plasmid (h) - sc-44101-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SHP shRNA (h) Lentiviral Particles - sc-44101-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SHP/NR0B2/Nuclear Receptor SHP RNAi - H00008431-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU156631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2483 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2483 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02708 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02708

NR0B2 siRNA (Human) - CRH5522 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SHP HDR Plasmid (h2) - sc-400964-HDR-2 from Santa Cruz Biotechnology

Prices $385.00
Sizes 20 µg
Species Reactivities Human

SHP CRISPR/Cas9 KO Plasmid (h2) - sc-400964-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $385.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human NR0B2 (NM_021969.2) - SHH354624 from Creative biogene

Category siRNA
Species Reactivities Human

NR0B2 shRNA Plasmid (Human) - CHH5522 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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