| Gene Symbol |
NR0B2
|
| Entrez Gene |
8431
|
| Alt Symbol |
SHP, SHP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 0, group B, member 2
|
| Other Description |
nuclear receptor SHP|nuclear receptor subfamily 0 group B member 2|orphan nuclear receptor SHP|small heterodimer partner
|
| Swissprots |
Q5QP36 F1D8P5 Q15466
|
| Accessions |
AAC41998 BAB68530 EAX07781 Q15466 AA872285 AI457167 AK310048 BC030207 AAH30207 DA930064 HQ692833 ADZ17344 XM_011542297 XP_011540599 NM_021969 NP_068804
|
| Function |
Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. {ECO:0000269|PubMed:14752053}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14752053}. Cytoplasm {ECO:0000269|PubMed:14752053}. Note=Colocalizes with NEUROD1 in the nucleus.
|
| Tissue Specificity |
Liver. Low levels of expression were detected in heart and pancreas. {ECO:0000269|PubMed:8650544}.
|
| Top Pathways |
Bile secretion
|
![Western Blot: Nuclear Receptor SHP Overexpression Lysate (Adult Normal) [NBL1-13765] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Nuclear Receptor SHP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4522_Nuclear%2520Receptor%2520SHP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13765-img0002.jpg)